Literature DB >> 10816308

Cell replacement therapies for central nervous system disorders.

A Björklund1, O Lindvall.   

Abstract

In animal models, immature neural precursors can replace lost neurons, restore function and promote brain self-repair. Clinical trials in Parkinson's disease suggest that similar approaches may also work in the diseased human brain. But how realistic is it that cell replacement can be developed into effective clinical therapy?

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Mesh:

Year:  2000        PMID: 10816308     DOI: 10.1038/75705

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN: 1097-6256            Impact factor:   24.884


  170 in total

1.  Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model.

Authors:  Lars M Bjorklund; Rosario Sánchez-Pernaute; Sangmi Chung; Therese Andersson; Iris Yin Ching Chen; Kevin St P McNaught; Anna-Liisa Brownell; Bruce G Jenkins; Claes Wahlestedt; Kwang-Soo Kim; Ole Isacson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-08       Impact factor: 11.205

2.  Restorative plasticity of dopamine neuronal transplants depends on the degree of hemispheric dominance.

Authors:  G Nikkhah; G Falkenstein; C Rosenthal
Journal:  J Neurosci       Date:  2001-08-15       Impact factor: 6.167

3.  Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons.

Authors:  K Sawamoto; N Nakao; K Kobayashi; N Matsushita; H Takahashi; K Kakishita; A Yamamoto; T Yoshizaki; T Terashima; F Murakami; T Itakura; H Okano
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

4.  Human stem cells as a model of motoneuron development and diseases.

Authors:  Yan Liu; Su-Chun Zhang
Journal:  Ann N Y Acad Sci       Date:  2010-06       Impact factor: 5.691

5.  Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene.

Authors:  K Sawamoto; N Nakao; K Kakishita; Y Ogawa; Y Toyama; A Yamamoto; M Yamaguchi; K Mori; S A Goldman; T Itakura; H Okano
Journal:  J Neurosci       Date:  2001-06-01       Impact factor: 6.167

Review 6.  Bone marrow stem cells and polymer hydrogels--two strategies for spinal cord injury repair.

Authors:  Eva Syková; Pavla Jendelová; Lucia Urdzíková; Petr Lesný; Ales Hejcl
Journal:  Cell Mol Neurobiol       Date:  2006-04-22       Impact factor: 5.046

Review 7.  Neurogenesis and brain injury: managing a renewable resource for repair.

Authors:  Anna F Hallbergson; Carmen Gnatenco; Daniel A Peterson
Journal:  J Clin Invest       Date:  2003-10       Impact factor: 14.808

8.  Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS.

Authors:  Vít Herynek; Katerina Růzicková; Pavla Jendelová; Eva Syková; Milan Hájek
Journal:  MAGMA       Date:  2009-02-24       Impact factor: 2.310

9.  Electrophysiological properties of mouse cortical neuron progenitors differentiated in vitro and in vivo.

Authors:  Weizhen Wang; Kunlin Jin; Xiao-Ou Mao; Natasha Close; David A Greenberg; Zhi-Gang Xiong
Journal:  Int J Clin Exp Med       Date:  2008-03-06

10.  Factors influencing the differentiation of dopaminergic traits in transplanted neural stem cells.

Authors:  Ming Yang; Angela E Donaldson; Yubao Jiang; Lorraine Iacovitti
Journal:  Cell Mol Neurobiol       Date:  2003-10       Impact factor: 5.046

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