| Literature DB >> 10815794 |
H Murakami1, S Takada, N Hatsumi, A Yokohama, T Saitoh, H Uchiumi, T Maehara, T Matsushima, N Tsukamoto, K Morita, J Tamura, M Sawamura, M Karasawa.
Abstract
Two myeloma patients presented high fever with no signs or data indicating infection at diagnosis or relapse. Both patients had plasmablastic myeloma, and serum levels of lactic dehydrogenase (LDH) and CRP were extremely high. Plasmablastic morphology, high LDH, and CRP were recognized as poor prognostic factors, indicating a fulminant phase of multiple myeloma. Interleukin-6 (IL-6) was only high in measured cytokines. We proposed that IL-6 caused high fever and induced the fulminant phase in these 2 cases.Entities:
Mesh：
Substances：
Year: 2000 PMID： 10815794 DOI： 10.1002/(sici)1096-8652(200005)64:1<76::aid-ajh15>3.0.co;2-o
Source DB: PubMed Journal: Am J Hematol ISSN： 0361-8609 Impact factor: 10.047