Literature DB >> 10814478

Synthesis (and alternative proof of configuration) of the scyphostatin C(1')-C(20') trienoyl fragment.

T R Hoye1, M A Tennakoon.   

Abstract

[reaction--see text] Each of four diastereomers of structure 2, corresponding to the lipophilic side chain of scyphostatin (1), were prepared. Careful analysis of their NMR spectral data and comparison with those of the natural product corroborates the recently reported (Org. Lett. 2000, 2, 505) stereochemical assignment. A strategy for the stereoselective synthesis of 2 has been achieved.

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Year:  2000        PMID： 10814478     DOI： 10.1021/ol0058386

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

1.  Efficient and selective syntheses of (all-E)- and (6E,10Z)-2'-O-methylmyxalamides D via Pd-catalyzed alkenylation--carbonyl olefination synergy.

Authors:  Guangwei Wang; Zhihong Huang; Ei-Ichi Negishi
Journal:  Org Lett       Date:  2008-07-02       Impact factor: 6.005

2.  Highly stereoselective total synthesis of fully hydroxy-protected mycolactones A and B and their stereoisomerization upon deprotection.

Authors:  Guangwei Wang; Ning Yin; Ei-ichi Negishi
Journal:  Chemistry       Date:  2011-03-15       Impact factor: 5.236

3.  Highly(≥98%) Stereo- and Regioselective Trisubstituted Alkene Synthesis of Wide Applicability via 1-Halo-1-alkyne Hydroboration-Tandem Negishi-Suzuki Coupling or Organoborate Migratory Insertion Protocol.

Authors:  Shiqing Xu; Ching-Tien Lee; Honghua Rao; Ei-Ichi Negishi
Journal:  Adv Synth Catal       Date:  2011-11       Impact factor: 5.837

4.  Alkyne elementometalation-Pd-catalyzed cross-coupling. Toward synthesis of all conceivable types of acyclic alkenes in high yields, efficiently, selectively, economically, and safely: "green" way.

Authors:  Ei-Ichi Negishi; Guangwei Wang; Honghua Rao; Zhaoqing Xu
Journal:  J Org Chem       Date:  2010-05-21       Impact factor: 4.354

5.  An efficient and general route to reduced polypropionates via Zr-catalyzed asymmetric CC bond formation.

Authors:  Ei-Ichi Negishi; Ze Tan; Bo Liang; Tibor Novak
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-08       Impact factor: 11.205

6.  One-pot diastreoselective synthesis of highly functionalized cyclohexenones: 2-oxo-N,4,6-triarylcyclohex-3-enecarboxamides.

Authors:  Mir Rasul Mousavi; Malek Taher Maghsoodlou; Sayyed Mostafa Habibi-Khorassani
Journal:  Mol Divers       Date:  2014-08-06       Impact factor: 2.943

7.  Methyl 4,6-bis-(4-fluoro-phen-yl)-2-oxo-cyclo-hex-3-ene-1-carboxyl-ate.

Authors:  Hoong-Kun Fun; Madhukar Hemamalini; S Samshuddin; B Narayana; H S Yathirajan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-17

8.  Ethyl 6-(6-meth-oxy-2-naphth-yl)-2-oxo-4-(2-thien-yl)cyclo-hex-3-ene-1-carboxyl-ate.

Authors:  Hongqi Li; Anil N Mayekar; B Narayana; H S Yathirajan; W T A Harrison
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-06-10

9.  Toxicological Evaluation of Novel Cyclohexenone Derivative in an Animal Model through Histopathological and Biochemical Techniques.

Authors:  Muhammad Kamil; Arifa Fatima; Sami Ullah; Gowhar Ali; Rasool Khan; Naila Ismail; Mughal Qayum; Marius Irimie; Catalina Georgeta Dinu; Hanadi Talal Ahmedah; Maria Elena Cocuz
Journal:  Toxics       Date:  2021-05-25
  9 in total

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