Literature DB >> 10814366

A novel synthesis of 2-aryl-2H-indazoles via a palladium-catalyzed intramolecular amination reaction.

J J Song1, N K Yee.   

Abstract

[reaction: see text] A variety of 2-aryl-2H-indazoles were synthesized by the palladium-catalyzed intramolecular amination of the corresponding N-aryl-N(o-bromobenzyl)hydrazines. Of several sets of reaction conditions surveyed, the combination of Pd(OAc)2/dppf/tBuONa gave the best results. This method applies to a wide scope of substrates containing electron-donating and electron-withdrawing substituents.

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Year:  2000        PMID： 10814366     DOI： 10.1021/ol990409x

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Intramolecular Fe(II)-catalyzed N-O or N-N bond formation from aryl azides.

Authors:  Benjamin J Stokes; Carl V Vogel; Linda K Urnezis; Minjie Pan; Tom G Driver
Journal:  Org Lett       Date:  2010-06-18       Impact factor: 6.005

2.  Synthesis of 2H-indazoles by the [3 + 2] cycloaddition of arynes and sydnones.

Authors:  Chunrui Wu; Yuesi Fang; Richard C Larock; Feng Shi
Journal:  Org Lett       Date:  2010-05-21       Impact factor: 6.005

3.  Synthesis of 2H-indazoles by the [3 + 2] dipolar cycloaddition of sydnones with arynes.

Authors:  Yuesi Fang; Chunrui Wu; Richard C Larock; Feng Shi
Journal:  J Org Chem       Date:  2011-10-12       Impact factor: 4.354

4.  Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles.

Authors:  Mei-Huey Lin; Kung-Yu Liang; Chang-Hsien Tsai; Yu-Chun Chen; Hung-Chang Hsiao; Yi-Syuan Li; Chung-Hao Chen; Hau-Chun Wu
Journal:  Molecules       Date:  2016-02-19       Impact factor: 4.411
  4 in total

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