Literature DB >> 10813880

Parallel Synthesis of Alkyl Tetrazole Derivatives Using Solid Support Chemistry.

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Abstract

The synthesis of several omega-chloroalkyl tetrazoles and their subsequent attachment to a solid support is described. Using an in situ Finkelstein reaction, a variety of nucleophiles were alkylated and then cleaved from the resin to give pure alkyl tetrazole derivatives. A sample library of 5 x 6 demonstrates the general utility of this sequence.

Entities:  

Year:  2000        PMID： 10813880     DOI： 10.1021/cc990035z

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


  6 in total

Review 1.  Tetrazoles via Multicomponent Reactions.

Authors:  Constantinos G Neochoritis; Ting Zhao; Alexander Dömling
Journal:  Chem Rev       Date:  2019-02-01       Impact factor: 60.622

2.  Improved synthesis of 5-substituted 1H-tetrazoles via the [3+2] cycloaddition of nitriles and sodium azide catalyzed by silica sulfuric acid.

Authors:  Zhenting Du; Changmei Si; Youqiang Li; Yin Wang; Jing Lu
Journal:  Int J Mol Sci       Date:  2012-04-12       Impact factor: 6.208

3.  Sustainable Generation of Ni(OH)2 Nanoparticles for the Green Synthesis of 5-Substituted 1H-Tetrazoles: A Competent Turn on Fluorescence Sensing of H2O2.

Authors:  Mita Halder; Md Mominul Islam; Pritam Singh; Anupam Singha Roy; Sk Manirul Islam; Kamalika Sen
Journal:  ACS Omega       Date:  2018-07-23

4.  Synthesis of (E)-2-(1H-tetrazole-5-yl)-3-phenylacrylenenitrile derivatives catalyzed by new ZnO nanoparticles embedded in a thermally stable magnetic periodic mesoporous organosilica under green conditions.

Authors:  Sajedeh Safapoor; Mohammad G Dekamin; Arezoo Akbari; M Reza Naimi-Jamal
Journal:  Sci Rep       Date:  2022-06-24       Impact factor: 4.996

5.  Cu(ii) immobilized on Fe3O4@APTMS-DFX nanoparticles: an efficient catalyst for the synthesis of 5-substituted 1H-tetrazoles with cytotoxic activity.

Authors:  Faezeh Taghavi; Mostafa Gholizadeh; Amir Sh Saljooghi; Mohammad Ramezani
Journal:  Medchemcomm       Date:  2017-09-15       Impact factor: 3.597

6.  C-Terminal 1-Aminoethyltetrazole-Containing Oligopeptides as Novel Alanine Racemase Inhibitors.

Authors:  Laszlo A Kondacs; Sylvain Orenga; Rosaleen J Anderson; Emma C L Marrs; John D Perry; Mark Gray
Journal:  Molecules       Date:  2020-03-13       Impact factor: 4.411
  6 in total

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