| Literature DB >> 10811879 |
G W Small1, L M Ercoli, D H Silverman, S C Huang, S Komo, S Y Bookheimer, H Lavretsky, K Miller, P Siddarth, N L Rasgon, J C Mazziotta, S Saxena, H M Wu, M S Mega, J L Cummings, A M Saunders, M A Pericak-Vance, A D Roses, J R Barrio, M E Phelps.
Abstract
The major known genetic risk for Alzheimer's disease (AD), apolipoprotein E-4 (APOE-4), is associated with lowered parietal, temporal, and posterior cingulate cerebral glucose metabolism in patients with a clinical diagnosis of AD. To determine cognitive and metabolic decline patterns according to genetic risk, we investigated cerebral metabolic rates by using positron emission tomography in middle-aged and older nondemented persons with normal memory performance. A single copy of the APOE-4 allele was associated with lowered inferior parietal, lateral temporal, and posterior cingulate metabolism, which predicted cognitive decline after 2 years of longitudinal follow-up. For the 20 nondemented subjects followed longitudinally, memory performance scores did not decline significantly, but cortical metabolic rates did. In APOE-4 carriers, a 4% left posterior cingulate metabolic decline was observed, and inferior parietal and lateral temporal regions demonstrated the greatest magnitude (5%) of metabolic decline after 2 years. These results indicate that the combination of cerebral metabolic rates and genetic risk factors provides a means for preclinical AD detection that will assist in response monitoring during experimental treatments.Entities:
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Year: 2000 PMID： 10811879 PMCID： PMC18554 DOI： 10.1073/pnas.090106797
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205