Literature DB >> 10809862

Interleukin 4 receptor alpha chain polymorphism Gln551Arg is associated with adult atopic dermatitis in Japan.

N Oiso1, K Fukai, M Ishii.   

Abstract

Localization of a locus for atopy to chromosome 16p12-p11 and reported associations of Ile50Val and Gln551Arg polymorphisms in interleukin-4 receptor alpha chain (IL 4R gene) with atopy prompted us to sequence the gene in 27 adult atopic dermatitis (AD) and 29 non-atopic (non-AD) subjects. Among six known polymorphisms, Gln551Arg was significantly associated with AD (P = 0.01). This polymorphism was found to be heterozygous in six of 27 patients with AD but none of the 28 non-AD controls. Ile50Val, which was previously reported to be associated with atopic asthma in Japan, showed no association with AD in our group. Glu375Ala and Cys406Arg also showed no association with AD. The IL 4R gene should thus be considered a compelling candidate gene for AD.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10809862     DOI： 10.1046/j.1365-2133.2000.03485.x

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN： 0007-0963            Impact factor:   9.302


  20 in total

1.  [Genetics of common chronic inflammatory skin diseases : An update on atopic dermatitis and psoriasis].

Authors:  E Rodríguez; K Eyerich; S Weidinger
Journal:  Hautarzt       Date:  2011-02       Impact factor: 0.751

Review 2.  Eczema in early life: genetics, the skin barrier, and lessons learned from birth cohort studies.

Authors:  Jocelyn M Biagini Myers; Gurjit K Khurana Hershey
Journal:  J Pediatr       Date:  2010-08-24       Impact factor: 4.406

Review 3.  Environmental risk factors and their role in the management of atopic dermatitis.

Authors:  Robert Kantor; Jonathan I Silverberg
Journal:  Expert Rev Clin Immunol       Date:  2016-07-28       Impact factor: 4.473

Review 4.  The genetics of atopic dermatitis: recent findings and future options.

Authors:  Sabine Hoffjan; Jörg T Epplen
Journal:  J Mol Med (Berl)       Date:  2005-05-18       Impact factor: 4.599

Review 5.  Molecular biology of atopic dermatitis.

Authors:  Zhanglei Mu; Yan Zhao; Xiaojing Liu; Christopher Chang; Jianzhong Zhang
Journal:  Clin Rev Allergy Immunol       Date:  2014-10       Impact factor: 8.667

Review 6.  Genomics and proteomics of allergic disease.

Authors:  Masako Toda; Santa Jeremy Ono
Journal:  Immunology       Date:  2002-05       Impact factor: 7.397

Review 7.  The Genetics and Epigenetics of Atopic Dermatitis-Filaggrin and Other Polymorphisms.

Authors:  Yunsheng Liang; Christopher Chang; Qianjin Lu
Journal:  Clin Rev Allergy Immunol       Date:  2016-12       Impact factor: 8.667

8.  Genome-wide association analysis of canine atopic dermatitis and identification of disease related SNPs.

Authors:  Shona Hiedi Wood; Xiayi Ke; Tim Nuttall; Neil McEwan; William E Ollier; Stuart D Carter
Journal:  Immunogenetics       Date:  2010-01-05       Impact factor: 2.846

Review 9.  The genetics of atopic dermatitis.

Authors:  Yin-Hsiu Chien; Wuh-Liang Hwu; Bor-Luen Chiang
Journal:  Clin Rev Allergy Immunol       Date:  2007-12       Impact factor: 8.667

Review 10.  Molecular Genetic of Atopic dermatitis: An Update.

Authors:  Hani A Al-Shobaili; Ahmed A Ahmed; Naief Alnomair; Zeiad Abdulaziz Alobead; Zafar Rasheed
Journal:  Int J Health Sci (Qassim)       Date:  2016-01
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.