Literature DB >> 10809762

Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15.

A J Bean1, S Davanger, M F Chou, B Gerhardt, S Tsujimoto, Y Chang.   

Abstract

Hrs-2, via interactions with SNAP-25, plays a regulatory role on the exocytic machinery. We now show that Hrs-2 physically interacts with Eps15, a protein required for receptor-mediated endocytosis. The Hrs-2/Eps15 interaction is calcium dependent, inhibited by SNAP-25 and alpha-adaptin, and results in the inhibition of receptor-mediated endocytosis. Immunoelectron microscopy reveals Hrs-2 localization on the limiting membrane of multivesicular bodies, organelles in the endosomal pathway. These data show that Hrs-2 regulates endocytosis, delineate a biochemical pathway (Hrs-2-Eps15-AP2) in which Hrs-2 functions, and suggest that Hrs-2 acts to provide communication between endo- and exocytic processes.

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Year:  2000        PMID： 10809762     DOI： 10.1074/jbc.275.20.15271

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  21 in total

1.  Hrs recruits clathrin to early endosomes.

Authors:  C Raiborg; K G Bache; A Mehlum; E Stang; H Stenmark
Journal:  EMBO J       Date:  2001-09-03       Impact factor: 11.598

2.  ATP is required at an early step in compensatory endocytosis in synaptic terminals.

Authors:  R Heidelberger
Journal:  J Neurosci       Date:  2001-09-01       Impact factor: 6.167

Review 3.  Cargo- and compartment-selective endocytic scaffold proteins.

Authors:  Iwona Szymkiewicz; Oleg Shupliakov; Ivan Dikic
Journal:  Biochem J       Date:  2004-10-01       Impact factor: 3.857

4.  Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase.

Authors:  Christine A Parachoniak; Morag Park
Journal:  J Biol Chem       Date:  2008-12-24       Impact factor: 5.157

5.  Cell-free reconstitution of multivesicular body formation and receptor sorting.

Authors:  Wei Sun; Thomas A Vida; Natalie Sirisaengtaksin; Samuel A Merrill; Phyllis I Hanson; Andrew J Bean
Journal:  Traffic       Date:  2010-02-27       Impact factor: 6.215

6.  CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling.

Authors:  Qing Yan; Wei Sun; Pekka Kujala; Yasmin Lotfi; Thomas A Vida; Andrew J Bean
Journal:  Mol Biol Cell       Date:  2005-03-16       Impact factor: 4.138

7.  The C-terminal portion of the Hrs protein interacts with Tsg101 and interferes with human immunodeficiency virus type 1 Gag particle production.

Authors:  Fadila Bouamr; Brian R Houck-Loomis; Martha De Los Santos; Rebecca J Casaday; Marc C Johnson; Stephen P Goff
Journal:  J Virol       Date:  2006-12-20       Impact factor: 5.103

8.  STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif.

Authors:  Emi Mizuno; Kensuke Kawahata; Masaki Kato; Naomi Kitamura; Masayuki Komada
Journal:  Mol Biol Cell       Date:  2003-06-13       Impact factor: 4.138

9.  UBE4B protein couples ubiquitination and sorting machineries to enable epidermal growth factor receptor (EGFR) degradation.

Authors:  Natalie Sirisaengtaksin; Monica Gireud; Qing Yan; Yoshihisa Kubota; Denisse Meza; Jack C Waymire; Peter E Zage; Andrew J Bean
Journal:  J Biol Chem       Date:  2013-12-16       Impact factor: 5.157

10.  Evolution and origin of HRS, a protein interacting with Merlin, the Neurofibromatosis 2 gene product.

Authors:  Leonid V Omelyanchuk; Julia A Pertseva; Sarah S Burns; Long-Sheng Chang
Journal:  Gene Regul Syst Bio       Date:  2009-10-08
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