| Literature DB >> 10809183 |
M Ohmori1, K Harada, Y Kitoh, S Nagasaka, T Saito, A Fujimura.
Abstract
We determined circulatory polymorphonuclear leukocytes (PMN) functions of superoxide anion production, adhesion and aggregation in 38 type 2 diabetic patients with and without diabetic triopathy. Tumor necrosis factor (TNF)-alpha-stimulated superoxide production and N-formyl-methionyl-leucyl-phenylalanine (FMLP)-stimulated aggregation in diabetic patients with triopathy were significantly greater than those in diabetics without triopathy. The more diabetic complications existed, the more TNF-alpha-stimulated superoxide was produced by PMN. These results suggest that the activated PMN contributes to a progression of diabetic triopathy in type 2 diabetic patients.Entities:
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Year: 2000 PMID： 10809183 DOI： 10.1016/s0024-3205(00)00509-9
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037