D Chen1, Z Jin, F Xing. 1. Nanfang Hospital, First Military Medical University, Guangzhou.
Abstract
OBJECTIVES: To profile the changes in integrin beta 3 expression in cycling and early pregnant endometrium and its relationship with unexplained infertility. METHOD: Expression of integrin beta 3 on endometrium was detected in 56 normal cycling women during different menstrual phases or early pregnant women, and 9 cases with unexplained infertility during mid-luteal phase by immunohistochemistry technique. RESULTS: Integrin beta 3 was expressed only in the midluteal or pregnant endometrium(after cycle day 19). Compared with normal women, integrin beta 3 failed to express in the midluteal endometrium from women with unexplained infertility. CONCLUSIONS: Our findings suggest integrin beta 3 may play important roles in the process of implantation and decidualization. It might be a new reliable marker of uterine receptivity. Abnormal endometrial integrin beta 3 expression might be the major cause of unexplained infertility.
OBJECTIVES: To profile the changes in integrin beta 3 expression in cycling and early pregnant endometrium and its relationship with unexplained infertility. METHOD: Expression of integrin beta 3 on endometrium was detected in 56 normal cycling women during different menstrual phases or early pregnant women, and 9 cases with unexplained infertility during mid-luteal phase by immunohistochemistry technique. RESULTS:Integrin beta 3 was expressed only in the midluteal or pregnant endometrium(after cycle day 19). Compared with normal women, integrin beta 3 failed to express in the midluteal endometrium from women with unexplained infertility. CONCLUSIONS: Our findings suggest integrin beta 3 may play important roles in the process of implantation and decidualization. It might be a new reliable marker of uterine receptivity. Abnormal endometrialintegrin beta 3 expression might be the major cause of unexplained infertility.