OBJECTIVE: To determine the efficacy and safety of 25 micrograms misoprostol for labor induction in the third trimester of pregnancy. METHODS: 48 term pregnant women with single pregnant vertex present intact membrane were selected in study group. All case in study group indications for labor induction, without contra-indication of labor induction and misoprostol. The 48 women were randomly assigned A(25 micrograms) and B(50 micrograms) misoprostol groups. Misoprostol was placed in the posterior vaginal fornix every 4 to 6 hours. The maximum dose in 24 hours is 200 micrograms. Misoprostol was not given after either spontaneous rupture of membrane or beginning of active labor. RESULT: The sucesess rate of induction labor was groups 77.8%, 81.0% in group A and B, respectively. The average duration from administration of misoprostol to start of labor in two groups was 796.9 +/- 359.9 minutes and 807.4 +/- 405.2 minutes, respectively; the average duration from start of misoprostol use to vaginal delivery was 978.6 +/- 464.4 minutes, 977.5 +/- 421.4 minutes, respectively. The incidence of vaginal delivery had no statistics significant difference between two groups (P > 0.05). The incidence of hypertonic uterine contraction or hypertonic contractionchysystole with abnormal pattern of fetal monitoring in group A was lower than that of group B, but there was no significant difference (P > 0.05). CONCLUSION:25 micrograms misoprostol is an efficient and safe dosage for labor induction in term pregnancy.
RCT Entities:
OBJECTIVE: To determine the efficacy and safety of 25 micrograms misoprostol for labor induction in the third trimester of pregnancy. METHODS: 48 term pregnant women with single pregnant vertex present intact membrane were selected in study group. All case in study group indications for labor induction, without contra-indication of labor induction and misoprostol. The 48 women were randomly assigned A(25 micrograms) and B(50 micrograms) misoprostol groups. Misoprostol was placed in the posterior vaginal fornix every 4 to 6 hours. The maximum dose in 24 hours is 200 micrograms. Misoprostol was not given after either spontaneous rupture of membrane or beginning of active labor. RESULT: The sucesess rate of induction labor was groups 77.8%, 81.0% in group A and B, respectively. The average duration from administration of misoprostol to start of labor in two groups was 796.9 +/- 359.9 minutes and 807.4 +/- 405.2 minutes, respectively; the average duration from start of misoprostol use to vaginal delivery was 978.6 +/- 464.4 minutes, 977.5 +/- 421.4 minutes, respectively. The incidence of vaginal delivery had no statistics significant difference between two groups (P > 0.05). The incidence of hypertonic uterine contraction or hypertonic contractionchysystole with abnormal pattern of fetal monitoring in group A was lower than that of group B, but there was no significant difference (P > 0.05). CONCLUSION: 25 micrograms misoprostol is an efficient and safe dosage for labor induction in term pregnancy.