| Literature DB >> 10806482 |
X Li1, A Pontén, K Aase, L Karlsson, A Abramsson, M Uutela, G Bäckström, M Hellström, H Boström, H Li, P Soriano, C Betsholtz, C H Heldin, K Alitalo, A Ostman, U Eriksson.
Abstract
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.Entities:
Mesh：
Substances：
Year: 2000 PMID： 10806482 DOI： 10.1038/35010579
Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824