Literature DB >> 10806331

Calpain-3 gene expression is decreased during experimental cancer cachexia.

S Busquets1, C García-Martínez, B Alvarez, N Carbó, F J López-Soriano, J M Argilés.   

Abstract

The Yoshida AH-130 rat ascites hepatoma is a model system for studying the mechanisms involved in the protein hypercatabolism associated with cancer cachexia. The present study was aimed at investigating if the calpain-3 gene expression in skeletal muscle was affected by tumor growth. The results presented clearly show that calpain-3 gene expression is considerably reduced in experimental cancer cachexia, while there is a reciprocal change in the expression of the ubiquitin-dependent proteolytic system and in the ubiquitous m-calpain. The results, observed during cancer cachexia, suggest a potential counterregulatory role of calpain-3 in muscle proteolysis.

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Year:  2000        PMID： 10806331     DOI： 10.1016/s0304-4165(00)00050-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

1.  Molecular adaptations of neuromuscular disease-associated proteins in response to eccentric exercise in human skeletal muscle.

Authors:  L Féasson; D Stockholm; D Freyssenet; I Richard; S Duguez; J S Beckmann; C Denis
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2.  Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle.

Authors:  Kristian Vissing; Kristian Overgaard; Anders Nedergaard; Anne Fredsted; Peter Schjerling
Journal:  Eur J Appl Physiol       Date:  2008-03-14       Impact factor: 3.078

Review 3.  Calpain activity and muscle wasting in sepsis.

Authors:  Ira J Smith; Stewart H Lecker; Per-Olof Hasselgren
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-05-20       Impact factor: 4.310

Review 4.  Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks.

Authors:  Simon S Wing; Stewart H Lecker; R Thomas Jagoe
Journal:  Crit Rev Clin Lab Sci       Date:  2011-06-24       Impact factor: 6.250

Review 5.  Muscle alterations in the development and progression of cancer-induced muscle atrophy: a review.

Authors:  Megan E Rosa-Caldwell; Dennis K Fix; Tyrone A Washington; Nicholas P Greene
Journal:  J Appl Physiol (1985)       Date:  2019-11-14

6.  Cancer cachexia: mechanisms and clinical implications.

Authors:  Claire L Donohoe; Aoife M Ryan; John V Reynolds
Journal:  Gastroenterol Res Pract       Date:  2011-06-13       Impact factor: 2.260

7.  Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexia.

Authors:  P Costelli; R De Tullio; F M Baccino; E Melloni
Journal:  Br J Cancer       Date:  2001-04-06       Impact factor: 7.640

8.  Motor protein function in skeletal abdominal muscle of cachectic cancer patients.

Authors:  Sultan Taskin; Vera Isabell Stumpf; Jeannine Bachmann; Cornelia Weber; Marc Eric Martignoni; Oliver Friedrich
Journal:  J Cell Mol Med       Date:  2013-11-19       Impact factor: 5.310

Review 9.  Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia--can findings from animal models be translated to humans?

Authors:  Tara C Mueller; Jeannine Bachmann; Olga Prokopchuk; Helmut Friess; Marc E Martignoni
Journal:  BMC Cancer       Date:  2016-02-08       Impact factor: 4.430

10.  Interference with Ca2+-Dependent Proteolysis Does Not Alter the Course of Muscle Wasting in Experimental Cancer Cachexia.

Authors:  Fabrizio Pin; Valerio G Minero; Fabio Penna; Maurizio Muscaritoli; Roberta De Tullio; Francesco M Baccino; Paola Costelli
Journal:  Front Physiol       Date:  2017-04-19       Impact factor: 4.566
  10 in total

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