Literature DB >> 10806328

Unbiased whole-brain analysis of gray matter loss in Alzheimer's disease.

S A Rombouts1, F Barkhof, M P Witter, P Scheltens.   

Abstract

In patients with Alzheimer's disease, substantial tissue loss occurs in the medial temporal lobe. In this study, we applied a voxel-based, unbiased whole-brain analysis method to compare magnetic resonance imaging scans of seven patients with Alzheimer's disease and seven healthy elderly controls. Images were transformed to standard coordinate space and tested for gray matter loss in patients. We found symmetrical decreases of gray matter in patients in the hippocampus, and, unexpectedly, also in the head of the caudate nucleus and the insula. The exact role of these two structures in the symptomatology of Alzheimer's disease deserves further attention.

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Year:  2000        PMID： 10806328     DOI： 10.1016/s0304-3940(00)01067-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  41 in total

1.  Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry.

Authors:  G B Frisoni; C Testa; A Zorzan; F Sabattoli; A Beltramello; H Soininen; M P Laakso
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-12       Impact factor: 10.154

2.  3D maps localize caudate nucleus atrophy in 400 Alzheimer's disease, mild cognitive impairment, and healthy elderly subjects.

Authors:  S K Madsen; A J Ho; X Hua; P S Saharan; A W Toga; C R Jack; M W Weiner; P M Thompson
Journal:  Neurobiol Aging       Date:  2010-06-11       Impact factor: 4.673

3.  Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys.

Authors:  A A Willette; B B Bendlin; D G McLaren; E Canu; E K Kastman; K J Kosmatka; G Xu; A S Field; A L Alexander; R J Colman; R H Weindruch; C L Coe; S C Johnson
Journal:  Neuroimage       Date:  2010-03-15       Impact factor: 6.556

4.  Ventral striatal volume is associated with cognitive decline in older people: a population based MR-study.

Authors:  L W de Jong; Y Wang; L R White; B Yu; M A van Buchem; L J Launer
Journal:  Neurobiol Aging       Date:  2010-11-13       Impact factor: 4.673

5.  Comparison of different methodological implementations of voxel-based morphometry in neurodegenerative disease.

Authors:  Matthew L Senjem; Jeffrey L Gunter; Maria M Shiung; Ronald C Petersen; Clifford R Jack
Journal:  Neuroimage       Date:  2005-04-12       Impact factor: 6.556

6.  Episodic memory impairment in patients with Alzheimer's disease is correlated with entorhinal cortex atrophy. A voxel-based morphometry study.

Authors:  M Di Paola; E Macaluso; G A Carlesimo; F Tomaiuolo; K J Worsley; L Fadda; C Caltagirone
Journal:  J Neurol       Date:  2007-04-03       Impact factor: 4.849

7.  Imaging correlates of posterior cortical atrophy.

Authors:  Jennifer L Whitwell; Clifford R Jack; Kejal Kantarci; Stephen D Weigand; Bradley F Boeve; David S Knopman; Daniel A Drubach; David F Tang-Wai; Ronald C Petersen; Keith A Josephs
Journal:  Neurobiol Aging       Date:  2006-06-23       Impact factor: 4.673

8.  Cerebral perfusion correlates of conversion to Alzheimer's disease in amnestic mild cognitive impairment.

Authors:  A Caroli; C Testa; C Geroldi; F Nobili; L R Barnden; U P Guerra; M Bonetti; G B Frisoni
Journal:  J Neurol       Date:  2007-11-09       Impact factor: 4.849

9.  Compromised hemodynamic response in amyloid precursor protein transgenic mice.

Authors:  Thomas Mueggler; Christine Sturchler-Pierrat; Diana Baumann; Martin Rausch; Matthias Staufenbiel; Markus Rudin
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167

10.  Dynamics of gray matter loss in Alzheimer's disease.

Authors:  Paul M Thompson; Kiralee M Hayashi; Greig de Zubicaray; Andrew L Janke; Stephen E Rose; James Semple; David Herman; Michael S Hong; Stephanie S Dittmer; David M Doddrell; Arthur W Toga
Journal:  J Neurosci       Date:  2003-02-01       Impact factor: 6.167
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