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Literature DB >> 10805576

Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin.

Abstract

Streptomyces hygroscopicus ATCC 29253 produces rapamycin, elaiophylin and nigericin. Although elaiophylin has no activity against Candida albicans ATCC 11651, it markedly enhances rapamycin's antifungal activity. Nigericin has only weak activity on its own but it also enhances rapamycin action. Surprisingly, elaiophylin does not enhance nigericin activity on C. albicans.

Entities: Chemical Species

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Year: 2000 PMID： 10805576 DOI： 10.7164/antibiotics.53.158

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

13 in total

1. Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species.

Authors: Liping Gong; Yi Xiao; Qiang Liu; Sumei Li; Changsheng Zhang; Jinsong Liu
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun Date: 2010-12-23

2. Biotechnological preparation of the elaiophylin.

Authors: M Cikosová; M Blazsek; M Kubis; J Gajdosíková; G Borosová
Journal: Folia Microbiol (Praha) Date: 2004 Impact factor: 2.099

3. Evolutionary stability of antibiotic protection in a defensive symbiosis.

Authors: Tobias Engl; Johannes Kroiss; Marco Kai; Taras Y Nechitaylo; Aleš Svatoš; Martin Kaltenpoth
Journal: Proc Natl Acad Sci U S A Date: 2018-02-14 Impact factor: 11.205

4. Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method.

Authors: Michael W Xie; Fulai Jin; Heejun Hwang; Seungmin Hwang; Vikram Anand; Mara C Duncan; Jing Huang
Journal: Proc Natl Acad Sci U S A Date: 2005-05-09 Impact factor: 11.205

5. Discovery of the actinoplanic acid pathway in Streptomyces rapamycinicus reveals a genetically conserved synergism with rapamycin.

Authors: Peter Mrak; Philipp Krastel; Petra Pivk Lukančič; Jianshi Tao; Dominik Pistorius; Charles M Moore
Journal: J Biol Chem Date: 2018-10-16 Impact factor: 5.157

6. Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.

Authors: M C Cruz; A L Goldstein; J Blankenship; M Del Poeta; J R Perfect; J H McCusker; Y L Bennani; M E Cardenas; J Heitman
Journal: Antimicrob Agents Chemother Date: 2001-11 Impact factor: 5.191

Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin.

1. Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species.

2. Biotechnological preparation of the elaiophylin.

3. Evolutionary stability of antibiotic protection in a defensive symbiosis.

4. Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method.

5. Discovery of the actinoplanic acid pathway in Streptomyces rapamycinicus reveals a genetically conserved synergism with rapamycin.

6. Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.

Review 7. Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering.

8. Antiangiogenic Potential of Microbial Metabolite Elaiophylin for Targeting Tumor Angiogenesis.

9. Efomycins K and L From a Termite-Associated Streptomyces sp. M56 and Their Putative Biosynthetic Origin.

Review 10. Natural Occurrence, Bioactivity and Biosynthesis of Elaiophylin Analogues.