| Literature DB >> 10805513 |
S A Cole1, B D Mitchell, W C Hsueh, P Pineda, B A Beamer, A R Shuldiner, A G Comuzzie, J Blangero, J E Hixson.
Abstract
Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-gamma2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n=210) had significantly higher body mass index (P=0.015) and waist circumference (P=0.028) and significantly higher levels of serum leptin (P= 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-gamma, is responsible for this association with measures of obesity in Mexican Americans.Entities:
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Year: 2000 PMID： 10805513 DOI： 10.1038/sj.ijo.0801210
Source DB: PubMed Journal: Int J Obes Relat Metab Disord