F Sériès1, J A Simoneau, S St Pierre. 1. Unité de recherche, Centre de pneumologie de l'hôpital Laval, Université Laval, Québec, Canada. Frederic.Series@med.ulaval.ca
Abstract
OBJECTIVE: To determine whether differences exist in the morphology of upper airway muscles between apneic and non-apneic snorers DESIGN: Muscle characteristic analysis in patients undergoing upper airway surgery in a tertiary sleep center. SUBJECTS: 10 non-apneic snorers and 10 sleep apnea hypopnea syndrome (SAHS). MEASUREMENTS: Frequency distribution of musculus uvulae (MU) muscle fiber area determined from 475+/-207 (mean s.d.) and 697 +/- 165 type IIA fibers and 92 +/- 32 and 68 45 type I fibers in snorers and SAHS, respectively. RESULTS: Histochemical analyses of MU revealed as expected that type IIA fibers occupied a significantly larger area within that muscle in SAHS compared to Snorers (89.4 +/- 5.8% and 76.1 +/- 15.1% respectively, P= 0.01). No difference was found in the frequency distribution of type I and type IIA fiber areas between the two groups comparing the between-groups and within-group variance of individual area distributions found in snorers and SAHS. CONCLUSION: There is no difference in muscle fiber area frequency distribution between non-apneic snorers and SAHS patients. This suggests that musculus uvulae of these groups of patients does not have a specific prevalence of atrophic or hypertrophic muscle fibers.
OBJECTIVE: To determine whether differences exist in the morphology of upper airway muscles between apneic and non-apneic snorers DESIGN: Muscle characteristic analysis in patients undergoing upper airway surgery in a tertiary sleep center. SUBJECTS: 10 non-apneic snorers and 10 sleep apnea hypopnea syndrome (SAHS). MEASUREMENTS: Frequency distribution of musculus uvulae (MU) muscle fiber area determined from 475+/-207 (mean s.d.) and 697 +/- 165 type IIA fibers and 92 +/- 32 and 68 45 type I fibers in snorers and SAHS, respectively. RESULTS: Histochemical analyses of MU revealed as expected that type IIA fibers occupied a significantly larger area within that muscle in SAHS compared to Snorers (89.4 +/- 5.8% and 76.1 +/- 15.1% respectively, P= 0.01). No difference was found in the frequency distribution of type I and type IIA fiber areas between the two groups comparing the between-groups and within-group variance of individual area distributions found in snorers and SAHS. CONCLUSION: There is no difference in muscle fiber area frequency distribution between non-apneic snorers and SAHS patients. This suggests that musculus uvulae of these groups of patients does not have a specific prevalence of atrophic or hypertrophic muscle fibers.
Authors: Julian P Saboisky; Daniel W Stashuk; Andrew Hamilton-Wright; Andrea L Carusona; Lisa M Campana; John Trinder; Danny J Eckert; Amy S Jordan; David G McSharry; David P White; Sanjeev Nandedkar; William S David; Atul Malhotra Journal: Am J Respir Crit Care Med Date: 2011-10-20 Impact factor: 21.405
Authors: Andrew D Calvin; Felipe N Albuquerque; Francisco Lopez-Jimenez; Virend K Somers Journal: Metab Syndr Relat Disord Date: 2009-08 Impact factor: 1.894