Literature DB >> 10805163

Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them?

F Eckstein1.   

Abstract

The development of nucleoside phosphorothioates is described in its historical context. Examples of the interaction of phosphorothioate groups, present either in oligodeoxynucleotides or in DNA, with nucleases are presented. The structural features responsible for the resistance of the phosphorothioates toward degradation by nucleases are discussed, as are the possible reasons for the high-affinity interaction of phosphorothioate oligodeoxynucleotides with certain proteins.

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Year:  2000        PMID： 10805163     DOI： 10.1089/oli.1.2000.10.117

Source DB:  PubMed          Journal:  Antisense Nucleic Acid Drug Dev        ISSN： 1087-2906


  78 in total

1.  Inhibition of telomerase by 2'-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.

Authors:  A N Elayadi; A Demieville; E V Wancewicz; B P Monia; D R Corey
Journal:  Nucleic Acids Res       Date:  2001-04-15       Impact factor: 16.971

2.  Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.

Authors:  W Brad Wan; Michael T Migawa; Guillermo Vasquez; Heather M Murray; Josh G Nichols; Hans Gaus; Andres Berdeja; Sam Lee; Christopher E Hart; Walt F Lima; Eric E Swayze; Punit P Seth
Journal:  Nucleic Acids Res       Date:  2014-11-14       Impact factor: 16.971

3.  Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity.

Authors:  Bryan A Kraynack; Brenda F Baker
Journal:  RNA       Date:  2005-11-21       Impact factor: 4.942

Review 4.  Gene modulation for treating liver fibrosis.

Authors:  Kun Cheng; Ram I Mahato
Journal:  Crit Rev Ther Drug Carrier Syst       Date:  2007       Impact factor: 4.889

5.  Formation of S-Cl phosphorothioate adduct radicals in dsDNA S-oligomers: hole transfer to guanine vs disulfide anion radical formation.

Authors:  Amitava Adhikary; Anil Kumar; Brian J Palmer; Andrew D Todd; Michael D Sevilla
Journal:  J Am Chem Soc       Date:  2013-08-14       Impact factor: 15.419

6.  The high binding affinity of phosphorothioate-modified oligomers for Ff gene 5 protein is moderated by the addition of C-5 propyne or 2'-O-methyl modifications.

Authors:  Tung-Chung Mou; Donald M Gray
Journal:  Nucleic Acids Res       Date:  2002-02-01       Impact factor: 16.971

Review 7.  Modulation of polycystic kidney disease by non-coding RNAs.

Authors:  Harini Ramalingam; Matanel Yheskel; Vishal Patel
Journal:  Cell Signal       Date:  2020-01-23       Impact factor: 4.315

8.  A Novel and Intuitive Method of Displaying and Interacting with Mass Difference Information: Application to Oligonucleotide Drug Impurities.

Authors:  Stilianos G Roussis
Journal:  J Am Soc Mass Spectrom       Date:  2015-04-03       Impact factor: 3.109

Review 9.  Antisense approach to inflammatory bowel disease: prospects and challenges.

Authors:  Irene Marafini; Davide Di Fusco; Emma Calabrese; Silvia Sedda; Francesco Pallone; Giovanni Monteleone
Journal:  Drugs       Date:  2015-05       Impact factor: 9.546

10.  Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology.

Authors:  Salvatore J Orlando; Yolanda Santiago; Russell C DeKelver; Yevgeniy Freyvert; Elizabeth A Boydston; Erica A Moehle; Vivian M Choi; Sunita M Gopalan; Jacqueline F Lou; James Li; Jeffrey C Miller; Michael C Holmes; Philip D Gregory; Fyodor D Urnov; Gregory J Cost
Journal:  Nucleic Acids Res       Date:  2010-06-08       Impact factor: 16.971
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