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Literature DB >> 1080476

Human T-lymphocyte rosette formation: inhibition by cytochalasin B.

Abstract

The effects of cytochalasin B, colchicine and vinblastine on the rosette formation of human T lymphocytes with neuraminidase-treated human erythrocytes (nHRBC) and with sheep red blood cells (SRBC) have been studied. Pretreatment of the lymphocytes with cytochalasin B which affects microfilament action reversibly inhibits both nHRBC and SRBC rosette formation. Colchicine and vinblastine known to interact with microtubules causes no major reduction in rosette-forming cells. The results suggest that normally functioning microfilaments are necessary for nHRBC and SRBC rosetting, whereas microtubules are not essential for the blinding of the erythrocytes to the lymphocytes.

Entities: Chemical Gene Species

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Year: 1975 PMID： 1080476 PMCID： PMC1445942

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

25 in total

10. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.

Authors: M Jondal; G Holm; H Wigzell
Journal: J Exp Med Date: 1972-08-01 Impact factor: 14.307

1 in total

1. Spontaneous rosette formation by lymphocytes. Differential effect of cytochalasin B on thymocytes and thymus-related peripheral blood lymphocytes in the guinea-pig.

Authors: T Radaszkiewicz; D Kotz; H Denk
Journal: Clin Exp Immunol Date: 1976-09 Impact factor: 4.330

1 in total

Human T-lymphocyte rosette formation: inhibition by cytochalasin B.

1. Binding of sheep erythrocytes to human lymphocytes. A probable marker of T lymphocytes.

2. Antigen-T lymphocyte interactions: inhibition by cytochalasin B.

3. Cytochalasin B. Dissociation of pinocytosis and phagocytosis by peritoneal macrophages.

4. Role of contractile microfilaments in macrophage movement and endocytosis.

5. Binding of sheep red blood cells to a large population of human lymphocytes.

6. Rosette-forming lymphocytes in normals and patients with malignant lymphomas.

7. Effects of cytochalasins on mammalian cells.

8. The human rosette-forming cell as a marker of a population of thymus-derived cells.

9. The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein.

10. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.

1. Spontaneous rosette formation by lymphocytes. Differential effect of cytochalasin B on thymocytes and thymus-related peripheral blood lymphocytes in the guinea-pig.