Literature DB >> 10804580

Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor.

A J Phillips1, Y Uto, P Wipf, M J Reno, D R Williams.   

Abstract

[formula: see text] A mild and highly efficient cyclization of beta-hydroxy amides to oxazolines is described using DAST and Deoxo-Fluor reagents. A one-pot protocol for the synthesis of oxazoles from beta-hydroxy amides is also presented.

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Year:  2000        PMID： 10804580     DOI： 10.1021/ol005777b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  41 in total

1.  Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.

Authors:  Garrett C Moraski; Mayland Chang; Adriel Villegas-Estrada; Scott G Franzblau; Ute Möllmann; Marvin J Miller
Journal:  Eur J Med Chem       Date:  2010-01-14       Impact factor: 6.514

2.  Methodology for the Synthesis of Substituted 1,3-Oxazoles.

Authors:  David R Williams; Liangfeng Fu
Journal:  Synlett       Date:  2009-12-22       Impact factor: 2.454

3.  UTILIZTION OF THE SUZUKI COUPLING TO ENHANCE THE ANTITUBERCULOSIS ACTIVITY OF ARYL OXAZOLES.

Authors:  Garrett C Moraski; Scott G Franzblau; Marvin J Miller
Journal:  Heterocycles       Date:  2010-03-01       Impact factor: 0.831

4.  One pot direct synthesis of amides or oxazolines from carboxylic acids using Deoxo-Fluor reagent.

Authors:  Cyrous O Kangani; David E Kelley
Journal:  Tetrahedron Lett       Date:  2005-12-19       Impact factor: 2.415

5.  N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.

Authors:  Jonathan A Stefely; Rahul Palchaudhuri; Patricia A Miller; Rebecca J Peterson; Garrett C Moraski; Paul J Hergenrother; Marvin J Miller
Journal:  J Med Chem       Date:  2010-04-22       Impact factor: 7.446

6.  Novel carvedilol analogues that suppress store-overload-induced Ca2+ release.

Authors:  Chris D Smith; Aixia Wang; Kannan Vembaiyan; Jingqun Zhang; Cuihong Xie; Qiang Zhou; Guogen Wu; S R Wayne Chen; Thomas G Back
Journal:  J Med Chem       Date:  2013-11-05       Impact factor: 7.446

7.  Tempering the reactivities of postulated α-oxo gold carbenes using bidentate ligands: implication of tricoordinated gold intermediates and the development of an expedient bimolecular assembly of 2,4-disubstituted oxazoles.

Authors:  Yingdong Luo; Kegong Ji; Yuxue Li; Liming Zhang
Journal:  J Am Chem Soc       Date:  2012-10-11       Impact factor: 15.419

8.  General methodology for the preparation of 2,5-disubstituted-1,3-oxazoles.

Authors:  David R Williams; Liangfeng Fu
Journal:  Org Lett       Date:  2010-02-19       Impact factor: 6.005

9.  Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures.

Authors:  David C Young; Anne Kasmar; Garrett Moraski; Tan-Yun Cheng; Andrew J Walz; Jingdan Hu; Yanping Xu; Gregory W Endres; Adam Uzieblo; Dirk Zajonc; Catherine E Costello; Marvin J Miller; D Branch Moody
Journal:  J Biol Chem       Date:  2009-07-15       Impact factor: 5.157

10.  Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir.

Authors:  Arun K Ghosh; W Sean Fyvie; Margherita Brindisi; Melinda Steffey; Johnson Agniswamy; Yuan-Fang Wang; Manabu Aoki; Masayuki Amano; Irene T Weber; Hiroaki Mitsuya
Journal:  ChemMedChem       Date:  2017-11-24       Impact factor: 3.466
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