Literature DB >> 10804284

Effects of reproduction on spontaneous development of endometrial adenocarcinomas and mammary tumors in Donryu rats.

T Nagaoka1, K Takegawa, M Takeuchi, A Maekawa.   

Abstract

Effects of reproduction on spontaneous development of uterine endometrial adenocarcinomas and mammary tumors in Donryu rats were investigated. While the incidence of endometrial adenocarcinomas in Donryu rats was not influenced by a single reproductive experience (SRE), it showed a tendency to decrease in animals having three reproductive experiences (TRE), compared to the nulliparous case (NRE). In addition, both SRE and TRE animals showed delayed occurrence and decreased incidences and mean numbers of mammary tumors, along with reduced incidences of proliferative lesions in the pituitary gland and mucinous epithelium in the vagina. The appearance-time and incidences of persistent estrus in TRE rats were delayed and low, respectively, compared to the SRE and NRE values. The hormonal environment was altered in both groups, the prolactin level in TRE especially being decreased. These results suggest that suppression of the occurrence of endometrial adenocarcinomas and mammary tumors in rats experiencing reproduction is associated with change in the hormonal milieu.

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Year:  2000        PMID： 10804284      PMCID： PMC5926469          DOI： 10.1111/j.1349-7006.2000.tb00955.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  33 in total

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  3 in total

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Journal:  Jpn J Cancer Res       Date:  2002-02

Review 2.  Modeling Endometrial Cancer: Past, Present, and Future.

Authors:  Tom Van Nyen; Cristian P Moiola; Eva Colas; Daniela Annibali; Frédéric Amant
Journal:  Int J Mol Sci       Date:  2018-08-09       Impact factor: 5.923

3.  Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats.

Authors:  Anna Kakehashi; Midori Yoshida; Yoshiyuki Tago; Naomi Ishii; Takahiro Okuno; Min Gi; Hideki Wanibuchi
Journal:  Toxins (Basel)       Date:  2016-11-04       Impact factor: 4.546
  3 in total

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