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Literature DB >> 108039

Absence of oroticaciduria in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency.

H A Simmonds, C F Potter, A Sahota, J S Cameron, D R Webster, D M Becroft.

Abstract

Orotic acid excretion was normal when tested by three methods in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. These results do not support the speculation, based on the oroticaciduria observed by others, that the immunodeficiency in these disorders results from the inhibition of pyrimidine biosynthesis. An alternative hypothesis is discussed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1978 PMID： 108039 PMCID： PMC1537471

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

11 in total

1. Two dimensional thin-layer high-voltage electrophoresis and chromatography for the separation of urinary purines, pyrimidines and pyrazolopyrimidines.

Authors: H A Simmonds
Journal: Clin Chim Acta Date: 1969-02 Impact factor: 3.786

2. Hereditary orotic aciduria: long-term therapy with uridine and a trial of uracil.

Authors: D M Becroft; L I Phillips; A Simmonds
Journal: J Pediatr Date: 1969-11 Impact factor: 4.406

3. Hereditary orotic aciduria. II. A urinary screening test.

Authors: L E Rogers; F S Porter
Journal: Pediatrics Date: 1968-09 Impact factor: 7.124

4. A role for purine metabolism in the immune response: Adenosine-deaminase activity and deoxyadenosine catabolism.

Authors: H A Simmonds; G S Panayi; V Corrigall
Journal: Lancet Date: 1978-01-14 Impact factor: 79.321

5. Purine metabolism and immunodeficiency: urinary purine excretion as a diagnostic screening test in adenosine deaminase and purine nucleoside phosphorylase deficiency.

Authors: H A Simmonds; A Sahota; C F Potter; J S Cameron
Journal: Clin Sci Mol Med Date: 1978-05

1. Radioautographic visualization of differences in the pattern of [3H]uridine and [3H]orotic acid incorporation into the RNA of migrating columnar cells in the rat small intestine.

Authors: M Uddin; G G Altmann; C P Leblond
Journal: J Cell Biol Date: 1984-05 Impact factor: 10.539

1 in total

Absence of oroticaciduria in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency.

1. Two dimensional thin-layer high-voltage electrophoresis and chromatography for the separation of urinary purines, pyrimidines and pyrazolopyrimidines.

2. Hereditary orotic aciduria: long-term therapy with uridine and a trial of uracil.

3. Hereditary orotic aciduria. II. A urinary screening test.

4. A role for purine metabolism in the immune response: Adenosine-deaminase activity and deoxyadenosine catabolism.

5. Purine metabolism and immunodeficiency: urinary purine excretion as a diagnostic screening test in adenosine deaminase and purine nucleoside phosphorylase deficiency.

6. Orotic aciduria in two unrelated patients with inherited deficiencies of purine nucleoside phosphorylase.

7. Purine metabolism in adenosine deaminase deficiency.

8. Purine dysfunction in cells from patients with adenosine deaminase deficiency.

9. Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells: role of adenosine deaminase.

10. Lethality of adenosine for cultured mammalian cells by interference with pyrimidine biosynthesis.

1. Radioautographic visualization of differences in the pattern of [3H]uridine and [3H]orotic acid incorporation into the RNA of migrating columnar cells in the rat small intestine.