Literature DB >> 10803363

Characterization of a novel polycystic kidney rat model with accompanying polycystic liver.

M Katsuyama1, T Masuyama, I Komura, T Hibino, H Takahashi.   

Abstract

A polycystic kidney rat model is being established from a Crj:CD (SD) rat strain. Unlike existing animal models of polycystic kidney disease, this mutant rat has a completely polycystic liver. Mating experiments revealed that the phenotype is controlled by an autosomal recessive gene. We propose that this gene be tentatively called the "rpc" gene.

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Year:  2000        PMID: 10803363     DOI: 10.1538/expanim.49.51

Source DB:  PubMed          Journal:  Exp Anim        ISSN: 0007-5124


  33 in total

1.  Role of genetic modifiers in an orthologous rat model of ARPKD.

Authors:  Caitlin C O'Meara; Matthew Hoffman; William E Sweeney; Shirng-Wern Tsaih; Bing Xiao; Howard J Jacob; Ellis D Avner; Carol Moreno
Journal:  Physiol Genomics       Date:  2012-06-05       Impact factor: 3.107

2.  Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease.

Authors:  James J Beaudoin; Jacqueline Bezençon; Yanguang Cao; Katsuhiko Mizuno; Sharin E Roth; William J Brock; Kim L R Brouwer
Journal:  Drug Metab Dispos       Date:  2018-11-30       Impact factor: 3.922

3.  Disease Modeling To Understand the Pathomechanisms of Human Genetic Kidney Disorders.

Authors:  Elisa Molinari; John A Sayer
Journal:  Clin J Am Soc Nephrol       Date:  2020-03-05       Impact factor: 8.237

Review 4.  Regulation of transport in the connecting tubule and cortical collecting duct.

Authors:  Alexander Staruschenko
Journal:  Compr Physiol       Date:  2012-04       Impact factor: 9.090

5.  Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model.

Authors:  Xiaofang Wang; Megan M Constans; Fouad T Chebib; Vicente E Torres; Lorenzo Pellegrini
Journal:  Am J Nephrol       Date:  2019-05-22       Impact factor: 3.754

Review 6.  Congenital hepatic fibrosis in autosomal recessive polycystic kidney disease.

Authors:  Jessica Wen
Journal:  Clin Transl Sci       Date:  2011-12-07       Impact factor: 4.689

7.  Increased YAP Activation Is Associated With Hepatic Cyst Epithelial Cell Proliferation in ARPKD/CHF.

Authors:  Lu Jiang; Lina Sun; Genea Edwards; Michael Manley; Darren P Wallace; Seth Septer; Chirag Manohar; Michele T Pritchard; Udayan Apte
Journal:  Gene Expr       Date:  2017-09-15

8.  Characterization of purinergic receptor expression in ARPKD cystic epithelia.

Authors:  Oleg Palygin; Daria V Ilatovskaya; Vladislav Levchenko; Christine A Klemens; Lashodya Dissanayake; Anna Marie Williams; Tengis S Pavlov; Alexander Staruschenko
Journal:  Purinergic Signal       Date:  2018-11-11       Impact factor: 3.765

9.  Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium.

Authors:  Tengis S Pavlov; Daria V Ilatovskaya; Oleg Palygin; Vladislav Levchenko; Oleh Pochynyuk; Alexander Staruschenko
Journal:  J Vis Exp       Date:  2015-09-01       Impact factor: 1.355

10.  Src inhibition ameliorates polycystic kidney disease.

Authors:  William E Sweeney; Rodo O von Vigier; Philip Frost; Ellis D Avner
Journal:  J Am Soc Nephrol       Date:  2008-04-02       Impact factor: 10.121

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