Literature DB >> 10802800

Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS. Optic Neuritis Study Group.

S L Hauser1, J R Oksenberg, R Lincoln, J Garovoy, R W Beck, S R Cole, P S Moke, K E Kip, R L Gal, D T Long.   

Abstract

The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds of probable or definite MS at 5 years (odds ratio, 1.92; 95% confidence interval, 1.01 to 3.67; p = 0.04). The association was most apparent among patients with signal abnormalities on baseline brain MRI.

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Year:  2000        PMID： 10802800     DOI： 10.1212/wnl.54.9.1859

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  7 in total

1.  HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis.

Authors:  A E Hensiek; S J Sawcer; R Feakes; J Deans; A Mander; E Akesson; R Roxburgh; F Coraddu; S Smith; D A S Compston
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-02       Impact factor: 10.154

2.  New developments in the treatment of optic neuritis.

Authors:  Thomas M Jenkins; Ahmed T Toosy
Journal:  Eye Brain       Date:  2010-06-17

3.  A genome-wide association study of brain lesion distribution in multiple sclerosis.

Authors:  Pierre-Antoine Gourraud; Michael Sdika; Pouya Khankhanian; Roland G Henry; Azadeh Beheshtian; Paul M Matthews; Stephen L Hauser; Jorge R Oksenberg; Daniel Pelletier; Sergio E Baranzini
Journal:  Brain       Date:  2013-02-13       Impact factor: 13.501

4.  Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.

Authors:  Cathy J Jensen; Jim Stankovich; Anneke Van der Walt; Melanie Bahlo; Bruce V Taylor; Ingrid A F van der Mei; Simon J Foote; Trevor J Kilpatrick; Laura J Johnson; Ella Wilkins; Judith Field; Patrick Danoy; Matthew A Brown; Justin P Rubio; Helmut Butzkueven
Journal:  PLoS One       Date:  2010-04-02       Impact factor: 3.240

5.  The relationship between HLA-DRB1 alleles and optic neuritis in Irish patients and the risk of developing multiple sclerosis.

Authors:  Ismail Tuwir; Ciaran Dunne; John Crowley; Tarik Saddik; Ray Murphy; Lorraine Cassidy
Journal:  Br J Ophthalmol       Date:  2007-10       Impact factor: 4.638

6.  Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures.

Authors:  D T Okuda; R Srinivasan; J R Oksenberg; D S Goodin; S E Baranzini; A Beheshtian; E Waubant; S S Zamvil; D Leppert; P Qualley; R Lincoln; R Gomez; S Caillier; M George; J Wang; S J Nelson; B A C Cree; S L Hauser; D Pelletier
Journal:  Brain       Date:  2008-11-20       Impact factor: 13.501

7.  Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study.

Authors:  Xin Huang; Feng-Qin Cai; Pei-Hong Hu; Yu-Lin Zhong; Ying Zhang; Rong Wei; Chong-Gang Pei; Fu-Qing Zhou; Yi Shao
Journal:  Neuropsychiatr Dis Treat       Date:  2015-12-16       Impact factor: 2.570
  7 in total

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