Literature DB >> 10801405

Fertility: purinergic receptors and the male contraceptive pill.

P M Dunn1.   

Abstract

Knockout mice lacking the P2X(1) receptor appear normal, but fail to breed. Analysis of these mutant mice clearly shows that purinergic co-transmission has a physiological role in the was deferens. These findings also raise the possibility of developing non-hormonal ways of regulating male fertility.

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Year:  2000        PMID: 10801405     DOI: 10.1016/s0960-9822(00)00436-x

Source DB:  PubMed          Journal:  Curr Biol        ISSN: 0960-9822            Impact factor:   10.834


  6 in total

1.  Methylene ATP analogs as modulators of extracellular ATP metabolism and accumulation.

Authors:  Sheldon M Joseph; Matthew A Pifer; Ronald J Przybylski; George R Dubyak
Journal:  Br J Pharmacol       Date:  2004-06-21       Impact factor: 8.739

2.  Male contraception via simultaneous knockout of α1A-adrenoceptors and P2X1-purinoceptors in mice.

Authors:  Carl W White; Yan-Ting Choong; Jennifer L Short; Betty Exintaris; Daniel T Malone; Andrew M Allen; Richard J Evans; Sabatino Ventura
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-02       Impact factor: 11.205

Review 3.  Purinergic signalling in the reproductive system in health and disease.

Authors:  Geoffrey Burnstock
Journal:  Purinergic Signal       Date:  2013-11-23       Impact factor: 3.765

4.  Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, potentiates ATP-gated P2X₁ receptor channel currents.

Authors:  Sun-Hye Choi; Hyeon-Joong Kim; Bo-Ra Kim; Tae-Joon Shin; Sung-Hee Hwang; Byung-Hwan Lee; Sang-Mok Lee; Hyewhon Rhim; Seung-Yeol Nah
Journal:  Mol Cells       Date:  2013-02-21       Impact factor: 5.034

Review 5.  Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation.

Authors:  Scott A Friedle; Marjorie A Curet; Jyoti J Watters
Journal:  Recent Pat CNS Drug Discov       Date:  2010-01

Review 6.  Introduction and perspective, historical note.

Authors:  Geoffrey Burnstock
Journal:  Front Cell Neurosci       Date:  2013-11-21       Impact factor: 5.505

  6 in total

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