Literature DB >> 10801178

Amplification of DNA sequences in polar bodies from human oocytes for diagnosis of mitochondrial disease.

D A Briggs, N J Power, V Lamb, A J Rutherford, R G Gosden.   

Abstract

When a preovulatory oocyte reinitiates meiosis, it sheds a cytoplasmic fragment containing mitochondria and a redundant set of chromosomes. We have detected DNA sequences from both the mitochondrial and nuclear genomes in polar bodies from unfertilised human oocytes, demonstrating the feasibility of diagnosing mitochondrial diseases before conception.

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Year:  2000        PMID： 10801178     DOI： 10.1016/s0140-6736(00)02171-1

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  3 in total

1.  Poor correlations in the levels of pathogenic mitochondrial DNA mutations in polar bodies versus oocytes and blastomeres in humans.

Authors:  Nadine Gigarel; Laetitia Hesters; David C Samuels; Sophie Monnot; Philippe Burlet; Violaine Kerbrat; Frédéric Lamazou; Alexandra Benachi; René Frydman; Josué Feingold; Agnes Rotig; Arnold Munnich; Jean-Paul Bonnefont; Nelly Frydman; Julie Steffann
Journal:  Am J Hum Genet       Date:  2011-04-08       Impact factor: 11.025

2.  Preimplantation genetic diagnosis for mitochondrial DNA disorders: ethical guidance for clinical practice.

Authors:  Annelien Bredenoord; Wybo Dondorp; Guido Pennings; Christine de Die-Smulders; Bert Smeets; Guido de Wert
Journal:  Eur J Hum Genet       Date:  2009-05-27       Impact factor: 4.246

3.  Correlation of the position and status of the polar body from the fertilized oocyte to the euploid status of blastocysts.

Authors:  Yongle Yang; Wei Tan; Changsheng Chen; Lei Jin; Bo Huang
Journal:  Front Genet       Date:  2022-09-20       Impact factor: 4.772
  3 in total

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