Literature DB >> 1080064

Kinetics of agonist conductance changes during hyperolarization at frog endplates.

P R Adams.   

Abstract

The effect of rapid hyperpolarization on acetylcholine- or carbachol-induced currents was studied at voltage clamped frog endplates. Following a hyperpolarizing step the agonist-induced conductance increased approximately exponentially to a new level. The rate constant for this process was smaller during hyperpolarization or lowered temperature, and was also smaller for acetylcholine than for carbachol. The results are interpreted in terms of a potential-dependent conformational change of the receptor.

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Year:  1975        PMID： 1080064      PMCID： PMC1666286          DOI： 10.1111/j.1476-5381.1975.tb07364.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

1.  A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors:  A L HODGKIN; A F HUXLEY
Journal:  J Physiol       Date:  1952-08       Impact factor: 5.182

2.  The effect of voltage on the time course of end-plate currents.

Authors:  K L Magleby; C F Stevens
Journal:  J Physiol       Date:  1972-05       Impact factor: 5.182

3.  The binding of acetylcholine to receptors and its removal from the synaptic cleft.

Authors:  B Katz; R Miledi
Journal:  J Physiol       Date:  1973-06       Impact factor: 5.182

4.  The statistical nature of the acetycholine potential and its molecular components.

Authors:  B Katz; R Miledi
Journal:  J Physiol       Date:  1972-08       Impact factor: 5.182

5.  Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction.

Authors:  C R Anderson; C F Stevens
Journal:  J Physiol       Date:  1973-12       Impact factor: 5.182
  5 in total
  43 in total

1.  Relaxation measurements on the acetylcholine receptor.

Authors:  R E Sheridan; H A Lester
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

2.  Voltage-dependence of drug-induced conductance in frog neuromuscular junction.

Authors:  E Neher; B Sakmann
Journal:  Proc Natl Acad Sci U S A       Date:  1975-06       Impact factor: 11.205

3.  Neuromuscular transmission in the isolated diaphragm of the dystrophic mouse (129 ReJ/dy.dy) [proceedings].

Authors:  J B Harris; R R Ribchester
Journal:  J Physiol       Date:  1976-12       Impact factor: 5.182

4.  Movements of radioactive potassium in isolated rat ganglia.

Authors:  C N Scholfield
Journal:  J Physiol       Date:  1977-06       Impact factor: 5.182

5.  Effect of external Cd2+ and other divalent cations on carbachol-activated non-selective cation channels in guinea-pig ileum.

Authors:  R Inoue
Journal:  J Physiol       Date:  1991-10       Impact factor: 5.182

6.  Voltage dependence of agonist responses at voltage-clamped frog endplates.

Authors:  P R Adams
Journal:  Pflugers Arch       Date:  1976-01-30       Impact factor: 3.657

7.  Voltage fluctuations at the frog sartorius motor endplate produced by a covalently attached activator.

Authors:  R N Cox; M Kawai; A Karlin; P W Brandt
Journal:  J Membr Biol       Date:  1979-12-14       Impact factor: 1.843

8.  Further kinetic analysis of the chemically modified acetylcholine receptor.

Authors:  A Steinacker; C Zuazaga
Journal:  Pflugers Arch       Date:  1987-08       Impact factor: 3.657

9.  Kinetics of acetylcholine-activated cation channel blockade by the calcium antagonist D-600 in Aplysia neurons.

Authors:  N T Slater; H L Haas; D O Carpenter
Journal:  Cell Mol Neurobiol       Date:  1983-12       Impact factor: 5.046

10.  Pharmacological and kinetic properties of alpha 4 beta 2 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.

Authors:  P Charnet; C Labarca; B N Cohen; N Davidson; H A Lester; G Pilar
Journal:  J Physiol       Date:  1992-05       Impact factor: 5.182
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