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Literature DB >> 10794681

Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents.

P J Gilligan¹, D W Robertson, R Zaczek.

Abstract

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Year: 2000 PMID： 10794681 DOI： 10.1021/jm990590f

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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11 in total

1. Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.

Authors: Jeffrey S Stehouwer; Matthew S Birnbaum; Ronald J Voll; Michael J Owens; Susan J Plott; Chase H Bourke; Michael A Wassef; Clinton D Kilts; Mark M Goodman
Journal: Bioorg Med Chem Date: 2015-06-19 Impact factor: 3.641

2. Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear.

Authors: D T Hubbard; B R Nakashima; I Lee; L K Takahashi
Journal: Neuroscience Date: 2007-10-05 Impact factor: 3.590

Review 3. CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome.

Authors: Y Taché; V Martinez; L Wang; M Million
Journal: Br J Pharmacol Date: 2004-04 Impact factor: 8.739

Review 4. From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases.

Authors: Yvette Taché; Stefan Brunnhuber
Journal: Ann N Y Acad Sci Date: 2008-12 Impact factor: 5.691

Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents.

1. Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.

2. Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear.

Review 3. CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome.

Review 4. From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases.

5. CRF1 receptor antagonists do not reverse pharmacological disruption of prepulse inhibition in rodents.

6. Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs.

7. Synthesis and Biological Evaluation of New CRH Analogues.

8. On the role of corticotropin-releasing hormone receptors in anxiety and depression.

9. Allosteric modulators of class B G-protein-coupled receptors.

10. Synthesis of new thiazolo[4,5-d]pyrimidines as Corticotropin releasing factor modulators.