| Literature DB >> 10793665 |
J Ravetch, J Gralla, D M Crothers.
Abstract
We studied the thermodynamic, kinetic and optical properties of the double helices formed by the series of self-complementary oligonucleotides, (AP)(n)GpC(pU)(n), 2 </= n </= 4, and found that the shortest helix, containing just 6 base pairs, is less stable than would be predicted from the properties of the larger molecules. It also shows a markedly smaller hyperchromism on melting than expected. These anomalous properties of a short helix indicate that one cannot always assume that base pair free energies and extinction coefficient changes are independent of helix size.Entities:
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Year: 1974 PMID： 10793665 PMCID： PMC343329 DOI： 10.1093/nar/1.1.109
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971