OBJECTIVES: We sought to determine the feasibility and utility of intraoperative radiolymphoscintigraphy as a screening procedure for the detection of occult metastatic disease in selected cases of head and neck squamous cell carcinoma (HNSCC). METHODS: Patients with accessible primary HNSCC and no evidence of metastatic disease who were already undergoing planned surgical resection of the primary tumor and elective neck dissection met the inclusion criteria. Before resection, a hand-held gamma probe was used to find the radiolabeled sentinel lymph node (SLN). The neck specimen was examined ex vivo by using the gamma probe; the SLN or SLNs were dissected free from the specimen and sent separately for histopathologic examination. RESULTS: At least one SLN was identified in all patients enrolled thus far. Four patients had microscopic carcinoma found in the SLN. Two of these had cancer only in the SLN, and two had disease both in the SLN and the remaining specimen. CONCLUSIONS: Intraoperative radiolymphoscintigraphy appears to be a feasible and promising procedure to aid the surgeon in more accurately detecting occult metastatic HNSCC.
OBJECTIVES: We sought to determine the feasibility and utility of intraoperative radiolymphoscintigraphy as a screening procedure for the detection of occult metastatic disease in selected cases of head and neck squamous cell carcinoma (HNSCC). METHODS:Patients with accessible primary HNSCC and no evidence of metastatic disease who were already undergoing planned surgical resection of the primary tumor and elective neck dissection met the inclusion criteria. Before resection, a hand-held gamma probe was used to find the radiolabeled sentinel lymph node (SLN). The neck specimen was examined ex vivo by using the gamma probe; the SLN or SLNs were dissected free from the specimen and sent separately for histopathologic examination. RESULTS: At least one SLN was identified in all patients enrolled thus far. Four patients had microscopic carcinoma found in the SLN. Two of these had cancer only in the SLN, and two had disease both in the SLN and the remaining specimen. CONCLUSIONS: Intraoperative radiolymphoscintigraphy appears to be a feasible and promising procedure to aid the surgeon in more accurately detecting occult metastatic HNSCC.
Authors: Francisco J Civantos; Robert P Zitsch; David E Schuller; Amit Agrawal; Russell B Smith; Richard Nason; Guy Petruzelli; Christine G Gourin; Richard J Wong; Robert L Ferris; Adel El Naggar; John A Ridge; Randal C Paniello; Kouros Owzar; Linda McCall; Douglas B Chepeha; Wendell G Yarbrough; Jeffrey N Myers Journal: J Clin Oncol Date: 2010-02-08 Impact factor: 44.544
Authors: Robert L Ferris; Liqiang Xi; Raja R Seethala; Jon Chan; Shaun Desai; Benjamin Hoch; William Gooding; Tony E Godfrey Journal: Clin Cancer Res Date: 2011-02-25 Impact factor: 12.531
Authors: Francisco J Civantos; Sandro J Stoeckli; Robert P Takes; Julia A Woolgar; Remco de Bree; Vinidh Paleri; Kenneth O Devaney; Alessandra Rinaldo; Carl E Silver; Vanni Mondin; Jochen A Werner; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2010-03-05 Impact factor: 2.503
Authors: C F Thompson; M A St John; G Lawson; T Grogan; D Elashoff; A H Mendelsohn Journal: Eur Arch Otorhinolaryngol Date: 2012-12-22 Impact factor: 2.503
Authors: Terry A Day; Betsy K Davis; M Boyd Gillespie; John K Joe; Megan Kibbey; Bonnie Martin-Harris; Brad Neville; Mary S Richardson; Steven Rosenzweig; Anand K Sharma; Michelle M Smith; Stacy Stewart; Robert K Stuart Journal: Curr Treat Options Oncol Date: 2003-02