| Literature DB >> 10793212 |
M Azuma1, T Kojimab, I Yokoyama, H Tajiri, K Yoshikawa, S Saga, C A Del Carpio.
Abstract
In recent years, several endogenous mammalian antibacterial peptides have been described. An amphipathic cationicalpha-helix is a common feature in many cases; therefore, other peptides with this characteristic might also possess antibiotic activity. In fact, a 30-mer peptide of apoprotein E 133-162 (LRVRLASHLRKLRKRLLRDADDLQKRLAVY) was found to have antibiotic activity comparable to those of a classic antibiotic (Gentamicin) and a neutrophil-derived antibiotic peptide (CAP18). Calculation of cationicity, hydrophobicity, and hydrophobic moment and the helical wheel diagram of apoprotein E 133-162 revealed close similarities to CAP18.Entities:
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Year: 2000 PMID： 10793212 DOI： 10.1016/s0196-9781(00)00165-0
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750