Literature DB >> 10790885

Novel expression of hypothalamic neuropeptide Y during postnatal development in the rat.

L K Singer1, J Kuper, R S Brogan, M S Smith, K L Grove.   

Abstract

Neuropeptide Y (NPY) is a potent orexigenic peptide. In the normal adult rat, hypothalamic NPY mRNA expression is limited to the arcuate nucleus (ARH). The purpose of this study was to characterize the developmental expression of NPY mRNA in the hypothalamus of the rat. In contrast to the normal adult rat, NPY mRNA was observed in the ARH, the dorsomedial hypothalamic nucleus (DMH) and the perifornical region (PFR) during development. NPY mRNA expression in all three regions increased progressively from postnatal days 0-4 (P0-4) to reach maximum levels at P16 and subsequently decreased to near adult levels by P30. The unique expression of NPY mRNA in the PFR and DMH may be important in establishing the proper management of energy homeostasis and body weight in the adult animal.

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Year:  2000        PMID： 10790885     DOI： 10.1097/00001756-200004070-00034

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  6 in total

1.  Mechanisms behind early life nutrition and adult disease outcome.

Authors:  Elena Velkoska; Margaret J Morris
Journal:  World J Diabetes       Date:  2011-08-15

2.  Large litter rearing improves leptin sensitivity and hypothalamic appetite markers in offspring of rat dams fed high-fat diet during pregnancy and lactation.

Authors:  Bo Sun; Lin Song; Kellie L K Tamashiro; Timothy H Moran; Jianqun Yan
Journal:  Endocrinology       Date:  2014-06-13       Impact factor: 4.736

3.  Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats.

Authors:  T Adage; A J Scheurink; S F de Boer; K de Vries; J P Konsman; F Kuipers; R A Adan; D G Baskin; M W Schwartz; G van Dijk
Journal:  J Neurosci       Date:  2001-05-15       Impact factor: 6.167

4.  Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice.

Authors:  Shin J Lee; Saurabh Verma; Stephanie E Simonds; Melissa A Kirigiti; Paul Kievit; Sarah R Lindsley; Alberto Loche; M Susan Smith; Michael A Cowley; Kevin L Grove
Journal:  J Neurosci       Date:  2013-09-18       Impact factor: 6.167

Review 5.  Critical determinants of hypothalamic appetitive neuropeptide development and expression: species considerations.

Authors:  B E Grayson; P Kievit; M S Smith; K L Grove
Journal:  Front Neuroendocrinol       Date:  2009-10-12       Impact factor: 8.606

6.  Ontogenesis of peptidergic neurons within the genoarchitectonic map of the mouse hypothalamus.

Authors:  Carmen Díaz; Nicanor Morales-Delgado; Luis Puelles
Journal:  Front Neuroanat       Date:  2015-01-12       Impact factor: 3.856
  6 in total

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