Literature DB >> 1079085

Studies on the thymic dependence of the immunoglobulin classes of the mouse (38570).

A D Bankhurst, P H Lambert, P A Miescher.   

Abstract

The influence of the thymus on serum immunoglobin (Ig) concentration was studied by a comparison of serum Ig levels in congenitally athymic (nu/nu) mice versus control littermate heterozygotes and adult thymectomized, irradiated, bone marrow reconsituted mice (ATx plus B) versus adult thymectomized, irradiated mice reconstituted with bone marrow and thymus (ATx plus BT). IN THE FORMER GROUP IgGl. IgA, and IgG2a were 8%, 17% and 31% of controls. IgM levels were increased (340%) compared to controls. When ATx plus B mice were compared to controls. When ATx plus B mice were compared with nonirradiated controls sigificant depressions were noted in serum IbGl and IgM. The only significant decrease in serum Ig levels between ATx plus B and ATx plus BT was in IgGl. These results are discussed in terms of the effects of thymic influence, residual T lymphocyte population differences between the two groups, and the effect of irradiation.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1079085     DOI： 10.3181/00379727-148-38570

Source DB:  PubMed          Journal:  Proc Soc Exp Biol Med        ISSN： 0037-9727


  18 in total

1.  Quantitative estimations of five classes of immunoglobulin in inbred mouse strains.

Authors:  S Natsuume-Sakai; K Motonishi; S Migita
Journal:  Immunology       Date:  1977-06       Impact factor: 7.397

2.  Nonrandom X chromosome inactivation in B cells from carriers of X chromosome-linked severe combined immunodeficiency.

Authors:  M E Conley; A Lavoie; C Briggs; P Brown; C Guerra; J M Puck
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

3.  The role of the host immune response in the development of tissue lesions associated with African trypanosomiasis in mice.

Authors:  B Galvao-Castro; A Hochmann; P H Lambert
Journal:  Clin Exp Immunol       Date:  1978-07       Impact factor: 4.330

4.  Sequential changes in serum immunoglobulin levels in young RFM mice with host-versus-graft disease.

Authors:  R C Hard
Journal:  Immunology       Date:  1980-04       Impact factor: 7.397

5.  Hyperactivity of donor B cells after neonatal induction of lymphoid chimerism in mice.

Authors:  M Goldman; D Abramowicz; P Lambert; P Vandervorst; C Bruyns; C Toussaint
Journal:  Clin Exp Immunol       Date:  1988-04       Impact factor: 4.330

6.  The effects of synthetic polymeric agents on immune responses of nude mice.

Authors:  M E Gershwin; B Merchant; A D Steinberg
Journal:  Immunology       Date:  1977-03       Impact factor: 7.397

7.  The distribution of cytoplasmic immunoglobulin containing cells over various lymphoid organs of congenitally athymic (nude) mice as a function of age.

Authors:  J J Haaijman; J Slingerland-Teunissen; R Benner; A Van Oudenaren
Journal:  Immunology       Date:  1979-02       Impact factor: 7.397

8.  Frequencies of background cytoplasmic Ig-containing cells in various lymphoid organs of athymic and euthymic mice as a function of age and immune status.

Authors:  A Van Oudenaren; J J Haaijman; R Benner
Journal:  Immunology       Date:  1984-04       Impact factor: 7.397

9.  Contrasting impairments in IgM and IgG responses of vitamin A-deficient mice.

Authors:  S M Smith; C E Hayes
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

10.  Immunoglobulin synthesis in nude (nu/nu), nu/+ and reconstituted nu/nu mice infected with a demyelinating strain of Semliki Forest virus.

Authors:  A J Suckling; S Jagelman; H E Webb
Journal:  Clin Exp Immunol       Date:  1982-02       Impact factor: 4.330
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.