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Literature DB >> 10790418

The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast.

Abstract

The Mre11p/Rad50p/Xrs2p complex is involved in the repair of double-strand DNA breaks, nonhomologous end joining, and telomere length regulation. TEL1 is primarily involved in telomere length regulation. By an epistasis analysis, we conclude that Tel1p and the Mre11p/Rad50p/Xrs2p complex function in a single pathway of telomere length regulation.

Entities: Gene Species

Mesh：

Substances：

Year: 2000 PMID： 10790418 PMCID： PMC1461057

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

24 in total

1. MEC1-dependent phosphorylation of Rad9p in response to DNA damage.

Authors: A Emili
Journal: Mol Cell Date: 1998-08 Impact factor: 17.970

Review 2. The many interfaces of Mre11.

Authors: J E Haber
Journal: Cell Date: 1998-11-25 Impact factor: 41.582

3. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing.

Authors: S J Boulton; S P Jackson
Journal: EMBO J Date: 1998-03-16 Impact factor: 11.598

4. ATM associates with and phosphorylates p53: mapping the region of interaction.

Authors: K K Khanna; K E Keating; S Kozlov; S Scott; M Gatei; K Hobson; Y Taya; B Gabrielli; D Chan; S P Lees-Miller; M F Lavin
Journal: Nat Genet Date: 1998-12 Impact factor: 38.330

Review 5. Recombination and joining: different means to the same ends.

Authors: R Kanaar; J H Hoeijmakers
Journal: Genes Funct Date: 1997-06

6. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae.

Authors: K M Kironmai; K Muniyappa
Journal: Genes Cells Date: 1997-07 Impact factor: 1.891

7. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.

Authors: Y Sanchez; B A Desany; W J Jones; Q Liu; B Wang; S J Elledge
Journal: Science Date: 1996-01-19 Impact factor: 47.728

8. The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.

Authors: T T Paull; M Gellert
Journal: Mol Cell Date: 1998-06 Impact factor: 17.970

9. The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae.

Authors: S E Porter; P W Greenwell; K B Ritchie; T D Petes
Journal: Nucleic Acids Res Date: 1996-02-15 Impact factor: 16.971

10. Telomere maintenance is dependent on activities required for end repair of double-strand breaks.

Authors: C I Nugent; G Bosco; L O Ross; S K Evans; A P Salinger; J K Moore; J E Haber; V Lundblad
Journal: Curr Biol Date: 1998-05-21 Impact factor: 10.834

76 in total

1. Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae.

Authors: Kyungjae Myung; Richard D Kolodner
Journal: Proc Natl Acad Sci U S A Date: 2002-03-26 Impact factor: 11.205

2. Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.

Authors: J C Mallory; T D Petes
Journal: Proc Natl Acad Sci U S A Date: 2000-12-05 Impact factor: 11.205

3. MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae.

Authors: Shinichiro Enomoto; Lynn Glowczewski; Judith Berman
Journal: Mol Biol Cell Date: 2002-08 Impact factor: 4.138

The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast.

1. MEC1-dependent phosphorylation of Rad9p in response to DNA damage.

Review 2. The many interfaces of Mre11.

3. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing.

4. ATM associates with and phosphorylates p53: mapping the region of interaction.

Review 5. Recombination and joining: different means to the same ends.

6. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae.

7. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.

8. The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.

9. The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae.

10. Telomere maintenance is dependent on activities required for end repair of double-strand breaks.

1. Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae.

2. Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.

3. MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae.

4. A quantitative assay for telomere protection in Saccharomyces cerevisiae.

5. Short telomeres induce a DNA damage response in Saccharomyces cerevisiae.

6. The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres.

7. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

8. The role of nonhomologous end-joining components in telomere metabolism in Kluyveromyces lactis.

9. MRX-dependent DNA damage response to short telomeres.

Review 10. DNA damage response at functional and dysfunctional telomeres.