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Literature DB >> 10789725

Altered expression of members of the IGF-axis in hepatoblastomas.

S G Gray¹, T Eriksson, C Ekström, S Holm, D von Schweinitz, P Kogner, B Sandstedt, T Pietsch, T J Ekström.

Abstract

Previous reports have demonstrated that expression of insulin-like growth factor 2 (IGF2) is altered in hepatoblastoma. Using RNAase protection analysis (RPA), we examined the gene expression for IGF1, IGF2, IGF1R, M6P/IGF2R, IGFBP-1 and IGFBP-2 in a series of hepatoblastomas with corresponding normal liver from the same individuals. The results show that the expression of the IGF-axis members included in the present study are altered between tumour and normal, and indicate that the IGF-axis may be involved in hepatoblastoma development.

Entities: Disease Gene

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Year: 2000 PMID： 10789725 PMCID： PMC2363389 DOI： 10.1054/bjoc.1999.1179

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

24 in total

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Journal: Br J Cancer Date: 2008-10-28 Impact factor: 7.640