Literature DB >> 10786632

Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase.

S Matsuda1, Y Ichigotani, T Okuda, T Irimura, S Nakatsugawa, M Hamaguchi.   

Abstract

A full-length cDNA encoding a novel protein was isolated and sequenced from a human hepatocellular cDNA library. This cDNA consists of 7037 base pairs and has a predicted open reading frame encoding 1924 amino acids. It possesses an RNA-helicase motif containing a DEXH-box in its amino-terminus and an RNase motif in the carboxy-terminus. From a striking homology to Caenorhabditis elegans K12H4.8, it might be a human homolog of the K12H4.8. PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 14q31 near the marker D14S605.

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Year:  2000        PMID: 10786632     DOI: 10.1016/s0167-4781(99)00221-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  18 in total

1.  RNA interference is mediated by 21- and 22-nucleotide RNAs.

Authors:  S M Elbashir; W Lendeckel; T Tuschl
Journal:  Genes Dev       Date:  2001-01-15       Impact factor: 11.361

2.  Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate.

Authors:  S M Elbashir; J Martinez; A Patkaniowska; W Lendeckel; T Tuschl
Journal:  EMBO J       Date:  2001-12-03       Impact factor: 11.598

3.  Silencing GIRK4 expression in human atrial myocytes by adenovirus-delivered small hairpin RNA.

Authors:  Xiongtao Liu; Jian Yang; Fujun Shang; Changming Hong; Wangang Guo; Bing Wang; Qiangsun Zheng
Journal:  Mol Biol Rep       Date:  2008-07-18       Impact factor: 2.316

4.  Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP.

Authors:  Haidi Zhang; Fabrice A Kolb; Vincent Brondani; Eric Billy; Witold Filipowicz
Journal:  EMBO J       Date:  2002-11-01       Impact factor: 11.598

5.  Ribonuclease activity and RNA binding of recombinant human Dicer.

Authors:  Patrick Provost; David Dishart; Johanne Doucet; David Frendewey; Bengt Samuelsson; Olof Rådmark
Journal:  EMBO J       Date:  2002-11-01       Impact factor: 11.598

Review 6.  Beyond the Protein-Coding Sequence: Noncoding RNAs in the Pathogenesis of Type 2 Diabetes.

Authors:  Johanna K DiStefano
Journal:  Rev Diabet Stud       Date:  2016-01-28

7.  Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems.

Authors:  N J Caplen; S Parrish; F Imani; A Fire; R A Morgan
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-31       Impact factor: 11.205

Review 8.  Role of microRNA-93 in regulation of angiogenesis.

Authors:  Fangxuan Li; Xiaofeng Liang; Ying Chen; Shixia Li; Juntian Liu
Journal:  Tumour Biol       Date:  2014-09-14

9.  siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells.

Authors:  Hiroaki Kawasaki; Eigo Suyama; Mayu Iyo; Kazunari Taira
Journal:  Nucleic Acids Res       Date:  2003-02-01       Impact factor: 16.971

10.  The locus control region activates serpin gene expression through recruitment of liver-specific transcription factors and RNA polymerase II.

Authors:  Hui Zhao; Richard D Friedman; R E K Fournier
Journal:  Mol Cell Biol       Date:  2007-05-25       Impact factor: 4.272

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