Literature DB >> 10786622

cDNA cloning of the mammalian sterol C5-desaturase and the expression in yeast mutant.

S Nishi1, H Nishino, T Ishibashi.   

Abstract

Sterol C5-desaturase (SC5D) cDNA is an enzyme that catalyzes the dehydrogenation to introduce C5-6 double bond into lathosterol in cholesterol biosynthesis. We have isolated and sequenced the cDNA clones encoding human and mouse SC5D. The functional complementation of a defective yeast mutant proves that the human and mouse cDNA clones encode SC5D. Mammalian SC5D was presumed as an integral membrane protein containing histidine residues conserved also in yeasts and plant.

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Year:  2000        PMID： 10786622     DOI： 10.1016/s0167-4781(99)00248-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  5 in total

1.  The MTE, a new core promoter element for transcription by RNA polymerase II.

Authors:  Chin Yan Lim; Buyung Santoso; Thomas Boulay; Emily Dong; Uwe Ohler; James T Kadonaga
Journal:  Genes Dev       Date:  2004-07-01       Impact factor: 11.361

2.  Sterol metabolism.

Authors:  Pierre Benveniste
Journal:  Arabidopsis Book       Date:  2002-03-27

3.  Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.

Authors:  Michael Lang; Sophie Murat; Andrew G Clark; Géraldine Gouppil; Catherine Blais; Luciano M Matzkin; Emilie Guittard; Takuji Yoshiyama-Yanagawa; Hiroshi Kataoka; Ryusuke Niwa; René Lafont; Chantal Dauphin-Villemant; Virginie Orgogozo
Journal:  Science       Date:  2012-09-28       Impact factor: 47.728

4.  Dynamic association rules for gene expression data analysis.

Authors:  Shu-Chuan Chen; Tsung-Hsien Tsai; Cheng-Han Chung; Wen-Hsiung Li
Journal:  BMC Genomics       Date:  2015-10-14       Impact factor: 3.969

5.  Lathosterolosis, a novel multiple-malformation/mental retardation syndrome due to deficiency of 3beta-hydroxysteroid-delta5-desaturase.

Authors:  Nicola Brunetti-Pierri; Gaetano Corso; Massimiliano Rossi; Paola Ferrari; Fiorella Balli; Francesco Rivasi; Ida Annunziata; Andrea Ballabio; Antonio Dello Russo; Generoso Andria; Giancarlo Parenti
Journal:  Am J Hum Genet       Date:  2002-08-20       Impact factor: 11.025
  5 in total

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