OBJECTIVE: It was our hypothesis that septic illness would alter both protein and energy metabolism in neonates, with elevations of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) serving as markers for these effects. STUDY DESIGN: A total of 31 infants with suspected sepsis were enrolled into four groups: septic, sick-nonseptic, healthy-nonseptic, and recovered septic infants. Degree of illness, oxygen consumption, nitrogen balance, urine 3-methylhistidine/creatinine (MeH/Cr), and TNF-alpha, IL-6, IL-1 beta, and C-reactive protein (CRP) were measured. RESULTS: Oxygen consumption increased, while nitrogen balance decreased and MeH/Cr increased with increasing degree of illness. Nitrogen balance improved on recovery from sepsis. IL-6 and CRP levels were elevated in septic infants compared with sick-nonseptic and healthy infants. CONCLUSION: Neonates experience a hypermetabolic response with increased nitrogen loss during septic illness, proportional to the degree of illness. Increased delivery of protein substrate may be nutritionally advantageous to the septic neonate.
OBJECTIVE: It was our hypothesis that septic illness would alter both protein and energy metabolism in neonates, with elevations of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) serving as markers for these effects. STUDY DESIGN: A total of 31 infants with suspected sepsis were enrolled into four groups: septic, sick-nonseptic, healthy-nonseptic, and recovered septic infants. Degree of illness, oxygen consumption, nitrogen balance, urine 3-methylhistidine/creatinine (MeH/Cr), and TNF-alpha, IL-6, IL-1 beta, and C-reactive protein (CRP) were measured. RESULTS:Oxygen consumption increased, while nitrogen balance decreased and MeH/Cr increased with increasing degree of illness. Nitrogen balance improved on recovery from sepsis. IL-6 and CRP levels were elevated in septic infants compared with sick-nonseptic and healthy infants. CONCLUSION: Neonates experience a hypermetabolic response with increased nitrogen loss during septic illness, proportional to the degree of illness. Increased delivery of protein substrate may be nutritionally advantageous to the septic neonate.
Authors: Lee A Denson; Scott A McDonald; Abhik Das; Diana E Schendel; Kristin Skogstrand; David M Hougaard; Seetha Shankaran; Rosemary D Higgins; Waldemar A Carlo; Richard A Ehrenkranz Journal: Am J Perinatol Date: 2016-07-25 Impact factor: 1.862
Authors: Kenny D Kronforst; Christy J Mancuso; Matthew Pettengill; Jana Ninkovic; Melanie R Power Coombs; Chad Stevens; Michael Otto; Carina Mallard; Xiaoyang Wang; Donald Goldmann; Ofer Levy Journal: PLoS One Date: 2012-09-06 Impact factor: 3.240
Authors: Lukas P Mileder; Julia Buchmayer; Nariae Baik-Schneditz; Bernhard Schwaberger; Nina Höller; Chad C Andersen; Michael J Stark; Gerhard Pichler; Berndt Urlesberger Journal: Front Pediatr Date: 2022-01-28 Impact factor: 3.418