Literature DB >> 10785619

Genetics and brain injury: apolipoprotein E.

R A Samatovicz1.   

Abstract

Apolipoprotein E (apo E) is a lipoprotein produced by astrocytes and microglia and has a proposed role in transporting lipids to injured neurons. There are three known isoforms of apo E, coded for by the APOE epsilon2, APOE epsilon3, and APOE epsilon4 genes. The APOE epsilon4 genotype has been implicated as a risk factor for Alzheimer's disease. Recent studies have suggested that APOE epsilon4 may influence the central nervous system's response to injury. This article presents an overview of the relationship between apo E, Alzheimer's disease, and head injury and reviews recent studies implicating APOE epsilon4 as a possible genetic determinant in recovery from head injury.

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Year:  2000        PMID： 10785619     DOI： 10.1097/00001199-200006000-00002

Source DB:  PubMed          Journal:  J Head Trauma Rehabil        ISSN： 0885-9701            Impact factor:   2.710


  9 in total

Review 1.  Management of sport-related concussion in young athletes.

Authors:  Dilip R Patel; Vandana Shivdasani; Robert J Baker
Journal:  Sports Med       Date:  2005       Impact factor: 11.136

2.  A model of neurodevelopmental risk and protection for preterm infants.

Authors:  Rita H Pickler; Jacqueline M McGrath; Barbara A Reyna; Nancy McCain; Mary Lewis; Sharon Cone; Paul Wetzel; Al Best
Journal:  J Perinat Neonatal Nurs       Date:  2010 Oct-Dec       Impact factor: 1.638

3.  Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa.

Authors:  John A Joska; Marc Combrinck; Victor G Valcour; Jacqueline Hoare; Felicity Leisegang; Anna Cecilia Mahne; Landon Myer; Dan J Stein
Journal:  J Neurovirol       Date:  2010-10       Impact factor: 2.643

4.  Apolipoprotein E genotype and traumatic brain injury in children--association with neurological outcome.

Authors:  Eva Brichtová; Libor Kozák
Journal:  Childs Nerv Syst       Date:  2007-10-12       Impact factor: 1.475

5.  Altered small-world properties of gray matter networks in breast cancer.

Authors:  S M Hadi Hosseini; Della Koovakkattu; Shelli R Kesler
Journal:  BMC Neurol       Date:  2012-05-28       Impact factor: 2.474

6.  Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging.

Authors:  Torgeir Hellstrøm; Nada Andelic; Ann-Marie G de Lange; Eirik Helseth; Kristin Eiklid; Lars T Westlye
Journal:  J Clin Med       Date:  2021-01-22       Impact factor: 4.241

7.  APOE-ε4 Is Associated With Reduced Verbal Memory Performance and Higher Emotional, Cognitive, and Everyday Executive Function Symptoms Two Months After Mild Traumatic Brain Injury.

Authors:  Torgeir Hellstrøm; Nada Andelic; Øyvor Øistensen Holthe; Eirik Helseth; Andres Server; Kristin Eiklid; Solrun Sigurdardottir
Journal:  Front Neurol       Date:  2022-02-16       Impact factor: 4.003

8.  Chronic traumatic encephalopathy: the dangers of getting "dinged".

Authors:  Shaheen E Lakhan; Annette Kirchgessner
Journal:  Springerplus       Date:  2012-03-12

Review 9.  Apolipoprotein E Epsilon 4 Genotype, Mild Traumatic Brain Injury, and the Development of Chronic Traumatic Encephalopathy.

Authors:  Hansen Deng; Angel Ordaz; Pavan S Upadhyayula; Eva M Gillis-Buck; Catherine G Suen; Caroline G Melhado; Nebil Mohammed; Troy Lam; John K Yue
Journal:  Med Sci (Basel)       Date:  2018-09-14
  9 in total

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