Literature DB >> 10784438

Inhibition of DNA topoisomerases by nidulalin A derivatives.

S Sato1, Y Fukuda, R Nakagawa, T Tsuji, K Umemura, T Andoh.   

Abstract

Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F390B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC50 values of 2.2 microM and 16 microM, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9 microM.

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Year:  2000        PMID： 10784438     DOI： 10.1248/bpb.23.511

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  2 in total

1.  Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991.

Authors:  Tetsuya Saito; Takeshi Itabashi; Daigo Wakana; Hisashi Takeda; Takashi Yaguchi; Ken-ichi Kawai; Tomoo Hosoe
Journal:  J Antibiot (Tokyo)       Date:  2015-08-26       Impact factor: 2.649

Review 2.  Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities.

Authors:  Najla Ali Alburae; Afrah E Mohammed; Hajer Saeed Alorfi; Adnan JamanTurki; Hani Zakaria Asfour; Walied Mohamed Alarif; Ahmed Abdel-Lateff
Journal:  Metabolites       Date:  2020-02-17
  2 in total

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