Literature DB >> 10782697

A convenient extension of the Wessely-Moser rearrangement for the synthesis of substituted alkylaminoflavones as neuroprotective agents in vitro.

R Larget1, B Lockhart, P Renard, M Largeron.   

Abstract

A series of 8-alkylamino-5,7-dihydroxyflavones was prepared from chrysine via a seven step sequence. The synthesis of their 6-alkylamino isomers could be subsequently accomplished through a convenient extension of the Wessely-Moser rearrangement. These compounds were found to be efficient neuroprotective agents in vitro.

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Year:  2000        PMID： 10782697     DOI： 10.1016/s0960-894x(00)00110-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Crystal structure of 4-(6-chloro-4-oxo-4H-chromen-3-yl)-2-methyl-amino-3-nitro-4H,5H-pyrano[3,2-c]chromen-5-one chloro-form monosolvate.

Authors:  Rajamani Raja; Subramani Kandhasamy; Paramasivam T Perumal; A SubbiahPandi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-06-27

2.  Current Strategies in Development of New Chromone Derivatives with Diversified Pharmacological Activities: A Review.

Authors:  Noor Ul Amin Mohsin; Muhammad Irfan; Shams Ul Hassan; Usman Saleem
Journal:  Pharm Chem J       Date:  2020-06-15       Impact factor: 0.837

3.  Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation.

Authors:  Yeong Sang Kim; Samantha G L Keyser; John S Schneekloth
Journal:  Bioorg Med Chem Lett       Date:  2014-01-11       Impact factor: 2.823

4.  Physiochemical, optical and biological activity of chitosan-chromone derivative for biomedical applications.

Authors:  Santosh Kumar; Joonseok Koh
Journal:  Int J Mol Sci       Date:  2012-05-18       Impact factor: 6.208

5.  Synthesis and evaluation of some novel chromone based dithiazoles as antimicrobial agents.

Authors:  Naureen Aggarwal; Vishal Sharma; Harpreet Kaur; Mohan Paul Singh Ishar
Journal:  Int J Med Chem       Date:  2013-11-27

6.  Chrysin Pretreatment Improves Angiotensin System, cGMP Concentration in L-NAME Induced Hypertensive Rats.

Authors:  Ramanathan Veerappan; Thekkumalai Malarvili
Journal:  Indian J Clin Biochem       Date:  2018-06-14

7.  Structural modification of olibergin A, an isoflavonoid, from Dalbergia stipulacea Roxb. and its cytotoxicity.

Authors:  Supakorn Arthan; Priyapan Posri; Sookkawath Walunchapruk; Thanaset Senawong; Chavi Yenjai
Journal:  RSC Adv       Date:  2022-06-16       Impact factor: 4.036

Review 8.  Bis[(l)prolinate-N,O]Zn: A water-soluble and recycle catalyst for various organic transformations.

Authors:  Roona Poddar; Arti Jain; Mazaahir Kidwai
Journal:  J Adv Res       Date:  2017-01-09       Impact factor: 10.479
  8 in total

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