Literature DB >> 10782694

Design, synthesis, and structure-activity relationship studies of ATP analogues as DNA gyrase inhibitors.

T Lübbers1, P Angehrn, H Gmünder, S Herzig, J Kulhanek.   

Abstract

We report herein the design and synthesis of ATP-analogues, namely 4-amino-pyrazolo[3,4-d]pyrimidines and 4-amino-pyrazolo[1,5-a][1,3,5]triazines, with DNA gyrase inhibitory activity. Among these series, some compounds exhibited promising antibacterial activity.

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Year:  2000        PMID： 10782694     DOI： 10.1016/s0960-894x(00)00109-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Thermodynamic computational approach to capture molecular recognition in the binding of different inhibitors to the DNA gyrase B subunit from Escherichia coli.

Authors:  Liane Saíz-Urra; Miguel Ángel Cabrera Pérez; Matheus Froeyen
Journal:  J Mol Model       Date:  2013-04-30       Impact factor: 1.810

2.  Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy.

Authors:  Yan Li; Ying Lei Wong; Fui Mee Ng; Boping Liu; Yun Xuan Wong; Zhi Ying Poh; Shuang Liu; Siew Wen Then; Michelle Yueqi Lee; Hui Qi Ng; Qiwei Huang; Alvin W Hung; Joseph Cherian; Jeffrey Hill; Thomas H Keller; CongBao Kang
Journal:  J Biol Chem       Date:  2016-06-30       Impact factor: 5.157

3.  Discovery of novel DNA gyrase inhibitors by high-throughput virtual screening.

Authors:  David A Ostrov; José A Hernández Prada; Patrick E Corsino; Kathryn A Finton; Nhan Le; Thomas C Rowe
Journal:  Antimicrob Agents Chemother       Date:  2007-08-06       Impact factor: 5.191

4.  Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with Bis-Pyrazolo-S-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities.

Authors:  Saied M Soliman; Raghdaa A Massoud; Hessa H Al-Rasheed; Ayman El-Faham
Journal:  Molecules       Date:  2021-06-14       Impact factor: 4.411

5.  Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity.

Authors:  Khadijah M Al-Zaydi; Hosam H Khalil; Ayman El-Faham; Sherine N Khattab
Journal:  Chem Cent J       Date:  2017-05-10       Impact factor: 4.215

6.  Design, synthesis and evaluation of carbazole derivatives as potential antimicrobial agents.

Authors:  Yi-Jie Xue; Ming-Yue Li; Xue-Jun Jin; Chang-Ji Zheng; Hu-Ri Piao
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

7.  Synthesis of novel dopamine derived multidirectional ligands from cyanuric chloride: structural and antimicrobial studies.

Authors:  Ziya Erdem Koç; Mustafa Onur Aladag; Ahmet Uysal
Journal:  EXCLI J       Date:  2013-05-07       Impact factor: 4.068

8.  Synthesis, structure and antibacterial activity of potent DNA gyrase inhibitors: N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide derivatives.

Authors:  Juan Sun; Peng-Cheng Lv; Yong Yin; Rong-Ju Yuan; Jian Ma; Hai-Liang Zhu
Journal:  PLoS One       Date:  2013-07-29       Impact factor: 3.240

9.  Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors.

Authors:  Sherine N Khattab; Hosam H Khalil; Adnan A Bekhit; Mohamed Mokbel Abd El-Rahman; Ayman El-Faham; Fernando Albericio
Journal:  Molecules       Date:  2015-09-02       Impact factor: 4.411
  9 in total

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