Literature DB >> 10782672

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors.

S Jin1, J S Kim, S P Sim, A Liu, D S Pilch, L F Liu, E J LaVoie.   

Abstract

A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity.

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Year:  2000        PMID： 10782672     DOI： 10.1016/s0960-894x(00)00087-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Topoisomerase I-mediated DNA cleavage induced by the minor groove-directed binding of bibenzimidazoles to a distal site.

Authors:  Qasim A Khan; Daniel S Pilch
Journal:  J Mol Biol       Date:  2006-10-13       Impact factor: 5.469

Review 2.  Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways.

Authors:  Yilun Sun; Liton Kumar Saha; Sourav Saha; Ukhyun Jo; Yves Pommier
Journal:  DNA Repair (Amst)       Date:  2020-07-10

3.  Biological evaluation of the activity of some benzimidazole-4,7-dione derivatives.

Authors:  Katarzyna Błaszczak-Świątkiewicz; Elżbieta Mikiciuk-Olasik
Journal:  Molecules       Date:  2014-09-26       Impact factor: 4.411

4.  STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage.

Authors:  Sun-Ok Kim; Krisada Sakchaisri; N R Thimmegowda; Thimmegowda N R; Nak Kyun Soung; Jae-Hyuk Jang; Young Sang Kim; Kyung Sang Lee; Yong Tae Kwon; Yukihiro Asami; Jong Seog Ahn; Raymond Leo Erikson; Bo Yeon Kim
Journal:  PLoS One       Date:  2013-01-22       Impact factor: 3.240

5.  Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties.

Authors:  Zena A Al-Mudaris; Aman S A Majid; Dan Ji; Ban A Al-Mudarris; Shih-Hsun Chen; Po-Huang Liang; Hasnah Osman; Shah Kamal Khan Jamal Din; Amin M S Abdul Majid
Journal:  PLoS One       Date:  2013-11-15       Impact factor: 3.240

6.  Biological evaluation of the toxicity and the cell cycle interruption by some benzimidazole derivatives.

Authors:  Katarzyna Błaszczak-Świątkiewicz; Joanna Sikora; Jacek Szymański; Marian Danilewicz; Elżbieta Mikiciuk-Olasik
Journal:  Tumour Biol       Date:  2016-03-01
  6 in total

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