| Literature DB >> 10782669 |
L W Hsin1, E L Webster, G P Chrousos, P W Gold, W C Eckelman, C Contoreggi, K C Rice.
Abstract
A series of fluoro-substituted 4-(dialkylamino)pyrrolo[2,3-d]pyrimidines was synthesized and their binding affinity for corticotropin-releasing hormone type 1 receptor (CRHR1) was investigated. Compounds 11a and 11b possessed very high CRHR1 affinity (Ki=3.5, 0.91 nM, respectively). They are promising candidates for the development of 18F-containing nonpeptide PET radioligands for CRHR1.Entities:
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Year: 2000 PMID： 10782669 DOI： 10.1016/s0960-894x(00)00071-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823