Literature DB >> 10782664

Isoxazolines and isoxazoles as factor Xa inhibitors.

J R Pruitt1, D J Pinto, M J Estrella, L L Bostrom, R M Knabb, P C Wong, M R Wright, R R Wexler.   

Abstract

3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis.

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Year:  2000        PMID： 10782664     DOI： 10.1016/s0960-894x(00)00097-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.

Authors:  Rami A Al-Horani; Akul Y Mehta; Umesh R Desai
Journal:  Eur J Med Chem       Date:  2012-06-23       Impact factor: 6.514

2.  Iron-catalyzed asymmetric epoxidation of β,β-disubstituted enones.

Authors:  Yasuhiro Nishikawa; Hisashi Yamamoto
Journal:  J Am Chem Soc       Date:  2011-05-16       Impact factor: 15.419

Review 3.  Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor.

Authors:  Pancras C Wong; Donald J P Pinto; Donglu Zhang
Journal:  J Thromb Thrombolysis       Date:  2011-05       Impact factor: 2.300

4.  Tissue factor, blood coagulation, and beyond: an overview.

Authors:  Arthur J Chu
Journal:  Int J Inflam       Date:  2011-09-20

5.  Isoxazole derivatives as new nitric oxide elicitors in plants.

Authors:  Anca Oancea; Emilian Georgescu; Florentina Georgescu; Alina Nicolescu; Elena Iulia Oprita; Catalina Tudora; Lucian Vladulescu; Marius-Constantin Vladulescu; Florin Oancea; Calin Deleanu
Journal:  Beilstein J Org Chem       Date:  2017-04-06       Impact factor: 2.883

6.  Fluorescent Small Molecules Are BIG Enough To Sense Biomacromolecule: Synthesis of Aromatic Thioesters and Understanding Their Interactions with ctDNA.

Authors:  Tamanna Mallick; Abhijit Karmakar; Shaikh Batuta; Giasuddin Ahamed; Sreeparna Das; Md Niharul Alam; Madhumathan Mukherjee; Nilanjana Das; Debabrata Mandal; Naznin Ara Begum
Journal:  ACS Omega       Date:  2018-01-11
  6 in total

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