PURPOSE: Electroretinograms to high-intensity flashes were obtained to determine the extent of rod and cone photoreceptor and postreceptor dysfunction in patients with primary open-angle glaucoma. METHODS: Full-field flash electroretinograms were obtained using brief high-intensity flashes. Dark-adapted (rod-dominated) and light-adapted (cone-dominated) electroretinogram responses were recorded to a "white" light as a function of flash intensity. The a-wave data were fitted with a model based on photopigment transduction to obtain values for the parameters of log Rmax (the maximum response) and log S (sensitivity). Oscillatory potentials were measured to the cone-dominated high-intensity flashes. Standard clinical 30 Hz flicker electroretinogram responses were recorded using a Grass photostimulator. RESULTS: Analysis of rod and cone a-wave data showed that log Rmax and log S values were within the normal range in nearly all of the patients. For some patients, oscillatory potentials were delayed beyond the normal range. CONCLUSION: Our results provide little evidence for widespread photoreceptor abnormalities in primary open-angle glaucoma.
PURPOSE: Electroretinograms to high-intensity flashes were obtained to determine the extent of rod and cone photoreceptor and postreceptor dysfunction in patients with primary open-angle glaucoma. METHODS: Full-field flash electroretinograms were obtained using brief high-intensity flashes. Dark-adapted (rod-dominated) and light-adapted (cone-dominated) electroretinogram responses were recorded to a "white" light as a function of flash intensity. The a-wave data were fitted with a model based on photopigment transduction to obtain values for the parameters of log Rmax (the maximum response) and log S (sensitivity). Oscillatory potentials were measured to the cone-dominated high-intensity flashes. Standard clinical 30 Hz flicker electroretinogram responses were recorded using a Grass photostimulator. RESULTS: Analysis of rod and cone a-wave data showed that log Rmax and log S values were within the normal range in nearly all of the patients. For some patients, oscillatory potentials were delayed beyond the normal range. CONCLUSION: Our results provide little evidence for widespread photoreceptor abnormalities in primary open-angle glaucoma.
Authors: Li Guo; Eduardo M Normando; Shereen Nizari; David Lara; M Francesca Cordeiro Journal: Invest Ophthalmol Vis Sci Date: 2010-08-04 Impact factor: 4.799
Authors: T Michael Nork; Charlene B Y Kim; Gregg A Heatley; Paul L Kaufman; Mark J Lucarelli; Leonard A Levin; James N Ver Hoeve Journal: Doc Ophthalmol Date: 2010-04-27 Impact factor: 2.379
Authors: Joseph M Harrison; Randolph D Glickman; Charles S Ballentine; Yolanda Trigo; Melanie A Pena; Pearl Kurian; Laura K Najvar; Neeru Kumar; Ankit H Patel; William E Sponsel; John R Graybill; William C Lloyd; Margaret M Miller; Gianmarco Paris; Fernando Trujillo; Aaron Miller; Robert Melendez Journal: Doc Ophthalmol Date: 2005-01 Impact factor: 2.379
Authors: Julie A Mocko; Moon Kim; Amanda E Faulkner; Yang Cao; Vincent T Ciavatta; Machelle T Pardue Journal: Invest Ophthalmol Vis Sci Date: 2011-06-13 Impact factor: 4.799
Authors: Martijn J Kanis; Hans G Lemij; Tos T J M Berendschot; Jan van de Kraats; Dirk van Norren Journal: Graefes Arch Clin Exp Ophthalmol Date: 2010-03-07 Impact factor: 3.117