| Literature DB >> 10782485 |
H Wang1, M G Nair, G M Strasburg, A M Booren, I Gray, D L Dewitt.
Abstract
Several flavonoids and isoflavonoids isolated from Balaton tart cherry were assayed for prostaglandin H endoperoxide synthase (PGHS-1) enzyme or cyclooxygenase isoform-1 (COX-1) activity. Genistein showed the highest COX-1 inhibitory activity among the isoflavonoids studied, with an IC50 value of 80 microM. Kaempferol gave the highest COX-1 inhibitory activity among the flavonoids tested, with an IC50 value of 180 microM. The structure-activity relationships of flavonoids and isoflavonoids revealed that hydroxyl groups at C4', C5 and C7 in isoflavonoids were essential for appreciable COX-1 inhibitory activity. Also, the C2-C3 double bond in flavonoids is important for COX-1 inhibitory activity. However, a hydroxyl group at the position decreased COX-1 inhibitory activity by flavonoids.Entities:
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Year: 2000 PMID： 10782485 DOI： 10.1016/S0944-7113(00)80016-1
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340