Literature DB >> 10782279

Novel practical synthesis of Kdn2en and its C-4 nitrogen-modified derivatives.

X L Sun1, N Sato, T Kai, K Furuhata.   

Abstract

A practical synthesis of Kdn2en and 4-amino-4-deoxy-Kdn2en has been achieved via a key intermediate, methyl 4,5,7,8,9-penta-O-acetyl-2,6-anhydro-3-deoxy-D-glycero-D-galacto-non-2- enonate, which has been prepared from Kdn in three steps in 91% overall yield.

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Year:  2000        PMID： 10782279     DOI： 10.1016/s0008-6215(99)00236-0

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  2 in total

Review 1.  KDN (deaminated neuraminic acid): dreamful past and exciting future of the newest member of the sialic acid family.

Authors:  Sadako Inoue; Ken Kitajima
Journal:  Glycoconj J       Date:  2006-07       Impact factor: 2.916

2.  The Aspergillus fumigatus sialidase is a 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase (KDNase): structural and mechanistic insights.

Authors:  Judith C Telford; Juliana H F Yeung; Guogang Xu; Milton J Kiefel; Andrew G Watts; Stefan Hader; Jefferson Chan; Andrew J Bennet; Margo M Moore; Garry L Taylor
Journal:  J Biol Chem       Date:  2011-01-19       Impact factor: 5.157
  2 in total

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