Literature DB >> 10782108

Dyskeratosis congenita, telomeres and human ageing.

R A Marciniak1, F B Johnson, L Guarente.   

Abstract

As normal humans age, telomeres shorten in tissues that contain dividing cells, and this has been proposed both as a cause of ageing and as a tumor-suppressor mechanism. The surprising finding that cells from individuals with the rare inherited disorder dyskeratosis congenita (DKC) have reduced levels of telomerase and shortened telomeres might provide the first direct genetic test of the function of telomeres in intact humans.

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Year:  2000        PMID： 10782108     DOI： 10.1016/s0168-9525(00)01984-3

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  12 in total

1.  Assembly mechanisms of RNA pseudoknots are determined by the stabilities of constituent secondary structures.

Authors:  Samuel S Cho; David L Pincus; D Thirumalai
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-05       Impact factor: 11.205

2.  Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita.

Authors:  Judy M Y Wong; Kathleen Collins
Journal:  Genes Dev       Date:  2006-10-02       Impact factor: 11.361

3.  Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions.

Authors:  Yun Lin; Amanda Damjanovic; E Jeffrey Metter; Huy Nguyen; Thai Truong; Kevin Najarro; Christa Morris; Dan L Longo; Ming Zhan; Luigi Ferrucci; Richard J Hodes; Nan-ping Weng
Journal:  Clin Sci (Lond)       Date:  2015-03       Impact factor: 6.124

4.  The effect of TERC haploinsufficiency on the inheritance of telomere length.

Authors:  Fred Goldman; Rachida Bouarich; Shashikant Kulkarni; Sara Freeman; Hong-Yan Du; Lea Harrington; Philip J Mason; Arturo Londoño-Vallejo; Monica Bessler
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-11       Impact factor: 11.205

Review 5.  The role of telomeres in the ageing of human skin.

Authors:  Erin M Buckingham; Aloysius J Klingelhutz
Journal:  Exp Dermatol       Date:  2011-03-03       Impact factor: 3.960

6.  [Dyskeratosis congenita in a 40-year-old patient].

Authors:  S Benoit; D Kraemer; E-B Bröcker; M Goebeler
Journal:  Hautarzt       Date:  2006-04       Impact factor: 0.751

Review 7.  Cellular aging and cancer.

Authors:  Peter J Hornsby
Journal:  Crit Rev Oncol Hematol       Date:  2010-08-11       Impact factor: 6.312

8.  Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing.

Authors:  Yuko Mochizuki; Jun He; Shashikant Kulkarni; Monica Bessler; Philip J Mason
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-07       Impact factor: 11.205

9.  Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations.

Authors:  Alberto Diaz de Leon; Jennifer T Cronkhite; Anna-Luise A Katzenstein; J David Godwin; Ganesh Raghu; Craig S Glazer; Randall L Rosenblatt; Carlos E Girod; Edward R Garrity; Chao Xing; Christine Kim Garcia
Journal:  PLoS One       Date:  2010-05-19       Impact factor: 3.240

10.  The Aspergillus nidulans swoC1 mutant shows defects in growth and development.

Authors:  Xiaorong Lin; Michelle Momany
Journal:  Genetics       Date:  2003-10       Impact factor: 4.562
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