| Literature DB >> 10781888 |
Abstract
The factors with human P450 substrate selectivity are reviewed, together with extensive tabulation of quantitative relationships between structure and activity for many species of P450 substrates, inducers and inhibitors. In addition, the physicochemical characteristics (logP and pK(a) values) of heptic microsomal P450 substrates are collated, such that comparisons can be made on the grounds of compound lipophilicities.Entities:
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Year: 2000 PMID： 10781888 DOI： 10.1016/s0300-483x(99)00207-3
Source DB: PubMed Journal: Toxicology ISSN： 0300-483X Impact factor: 4.221